about
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activityA unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activityDiaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformationDesign, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.Synthesis of a 6-CF-Substituted 2-Amino-dihydro-1,3-thiazine β-Secretase Inhibitor by N, N-Diethylaminosulfur Trifluoride-Mediated Chemoselective CyclizationRational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the BrainDiscovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation StabilizationDiscovery of an Extremely Potent Thiazine-Based β-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human DoseTrifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding BurdenStructure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2
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Q27684531-05C21E3F-296B-4AA5-8EA7-9C629875DB08Q27697666-4CB555F7-6BEA-4C7D-A54F-EAE4FB7DB432Q27700023-3FDB5E71-5B13-4647-8B52-C29C732800A5Q39732994-34329CEC-C86D-48A3-B8B9-B9F706283B19Q43636716-6B04095D-9510-4A9F-A107-DCD145074CE1Q58104708-377BBCC1-E257-43B6-B390-E3B2DFAD1EEDQ88589637-B6D2F193-A859-4FCD-B67A-AF190068FB32Q88727094-0739F0E1-F97F-4F46-8341-2BA811741AF2Q90252129-A83E9015-BD2B-4002-8EDF-525D02614FC4Q90965600-785735BC-6F87-40A9-BCCA-341C06E21F30Q91505998-76059975-0745-4C9E-8F7B-EC9640FD063E
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description
investigador
@es
researcher
@en
name
Ken-ichi Kusakabe
@en
type
label
Ken-ichi Kusakabe
@en
prefLabel
Ken-ichi Kusakabe
@en
P108
P31
P496
0000-0001-9055-8267