about
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cellsHydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathwayCaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell deathCadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell deathCadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.Curcumin disrupts the Mammalian target of rapamycin-raptor complex.Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network.Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion.Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression.Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cellsRapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis.Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway.The antitumor activity of the fungicide ciclopiroxHydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells.MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis.Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway.
P50
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P50
name
Lei Liu
@en
type
label
Lei Liu
@en
prefLabel
Lei Liu
@en