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Q37583704-3B8CBC20-1855-4DFA-8914-BB08D14233A1
Q37583704-3B8CBC20-1855-4DFA-8914-BB08D14233A1
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37583704-3B8CBC20-1855-4DFA-8914-BB08D14233A1
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.
P2860
Q37583704-3B8CBC20-1855-4DFA-8914-BB08D14233A1
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37583704-3B8CBC20-1855-4DFA-8914-BB08D14233A1
rank
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wasDerivedFrom
ef98f7a1e425f64300a87d0c50812c13e38cb80d
P2860
A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.