The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastomaCell biology. Metabolic control of cell deathMcl-1 ubiquitination: unique regulation of an essential survival protein.Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.MiR-223 promotes the cisplatin resistance of human gastric cancer cells via regulating cell cycle by targeting FBXW7.mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation.GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growthBay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells.Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells.EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRCβ-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cellsDistinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.Destabilization of akt promotes the death of myeloma cell lines.The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer.Ubiquitin ligases in oncogenic transformation and cancer therapy.A partnership with the proteasome; the destructive nature of GSK3.Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Turn down genes for WAT? Activation of anti-apoptosis pathways protects white adipose tissue in metabolically depressed thirteen-lined ground squirrels.FBXW7: a critical tumor suppressor of human cancers
P2860
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P2860
The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis.
description
2013 nî lūn-bûn
@nan
2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
@zh-sg
2013年學術文章
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name
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@en
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@nl
type
label
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@en
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@nl
prefLabel
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@en
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@nl
P2093
P2860
P356
P1433
P1476
The E3 ubiquitin ligases β-TrC ...... API-1, resulting in apoptosis.
@en
P2093
Baoxiang Guan
Fadlo R Khuri
Junghui Koo
Mingwei Chen
Shi-Yong Sun
Xingming Deng
P2860
P2888
P356
10.1186/1476-4598-12-146
P577
2013-11-22T00:00:00Z
P5875
P6179
1007440907