about
P688
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationDJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptorDJ-1 cooperates with PYCR1 in cell protection against oxidative stressParkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityThe Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosisRegulation of the VHL/HIF-1 pathway by DJ-1DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisDown regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibitionThe expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's diseaseParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageDJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathMitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesisDJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cellsInteraction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathDJ-1 has a role in antioxidative stress to prevent cell deathhsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondriaParkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residuesDJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBThe role of oxidative stress in Parkinson's diseaseOxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1DJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayRNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysHuman DJ-1 and its homologs are novel glyoxalasesDJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADDAssociation of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's diseaseMutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismMitochondrial localization of DJ-1 leads to enhanced neuroprotectionDJ-1 binds to mitochondrial complex I and maintains its activityGlucocerebrosidase is shaking up the synucleinopathiesNuclear translocation of DJ-1 during oxidative stress-induced neuronal cell deathDJ-1 is a copper chaperone acting on SOD1 activationDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorStructure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in ParkinsonismThe Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyteEvidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal DetoxificationGuanine glycation repair by DJ-1/Park7 and its bacterial homologs.Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro.Methylglyoxal-derived posttranslational arginine modifications are abundant histone marksReversible histone glycation is associated with disease-related changes in chromatin architecture
P921
Q21146396-71B68F5B-1692-4CD9-90FA-D8C14851CF26Q24291490-E889BF6B-36C7-47DE-AF30-B2C9B362AB9FQ24294657-CE0C8F5F-A3F8-44B2-94BB-172C3ABBAA2CQ24296667-193E43F0-A144-456C-9FC6-355046B1C7C5Q24298775-302B3230-8D36-40AE-9372-EA981DF2502AQ24298803-72938F2C-C582-44F9-822B-C16E6FFD30D4Q24299536-A1F84C56-AC07-40EB-8AB6-12BED1A4ECD6Q24300958-DCE3BC0B-8CC9-458D-AFD1-ABDBF0896DA6Q24301425-80374D1E-A07E-4EB9-A370-397654013B82Q24304102-8C47FB65-9F96-4FEC-9685-F88FD9AB98E4Q24304197-EFD5990E-4218-41C7-90A4-7EF4B2A132FFQ24304952-15F866A5-45F9-471B-BE56-4957AF9D2C7DQ24305442-ED33A295-6C90-4332-87A7-147F5D6A5948Q24306258-12001CE1-4160-4869-96BA-0E18F3C03B71Q24306270-A5D3950D-DAF2-4BC7-8D00-CE27DF27C832Q24306633-01C243EA-FD87-41DE-B846-0C9CC0FEC55DQ24306768-F1175854-D2BB-4AAF-93CA-8D253D2E2CABQ24306921-7CA9AA38-D850-4990-BC11-5BEE21FACD8EQ24307823-37FBFD67-7DAD-45DE-8C6E-6BA37C721C13Q24307946-30C61745-F3B9-4F92-9D88-48A91E1E37C5Q24309004-9A776968-DD0B-4774-888C-2A294B62D3C0Q24312506-849D3376-5D3B-4F80-A1A1-E28157FF5899Q24313263-01A3A5A1-8D8B-44BE-9C0C-8A73938B306FQ24316421-85F54185-4F4D-4DDD-AD83-C0D6AA7C53ACQ24316876-C6E2126B-095C-47CA-A927-5FA882319797Q24319830-CF5643CB-B13B-4332-A674-D8268FD1EA58Q24321359-81FD4162-3298-494A-93A8-C4E525E4E14BQ24324226-CC5E6876-310A-4D65-BA93-2A7C0EFD11FFQ24324507-67E5ECE2-8C99-41D9-8ED8-5D3E756AFE80Q24337392-D84C4C61-E2E4-4966-8854-11B3066CC77FQ24337858-3A8DB38D-2424-410F-9303-0EE81429A62BQ24338208-AB739E18-B8E8-4B76-8A39-4217F2BA3770Q24338249-A93ECB86-7114-4658-A495-7D930F6780D7Q24338804-EAF70038-5762-4D33-9836-D1BDECEE832BQ28596568-7019ED35-9013-4B86-AC74-66E682287F09Q28596604-A985F8FA-9E01-4883-97F7-D9D965FDE2B5Q41412797-E920D0DA-DE15-4362-9403-C0454C3E677FQ42373911-B8A05683-5B61-4332-91E8-A0E4B556234FQ58700276-10AEAA5D-9748-44B9-99B3-C02ED3450528Q64072026-308D6E36-45D2-4068-94A2-CA53561AD114
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Parkinsonism associated deglycase
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
Parkinsonism associated deglycase
@en
protéine deglycase DJ-1
@fr
type
label
Parkinsonism associated deglycase
@en
protéine deglycase DJ-1
@fr
altLabel
PARK7
@en
Parkinson disease (autosomal recessive, early onset) 7
@en
Parkinson disease protein 7
@en
epididymis secretory sperm binding protein Li 67p
@en
maillard deglycase
@en
oncogene DJ1
@en
parkinson protein 7
@en
protein DJ-1
@en
protein deglycase DJ-1
@en
protein/nucleic acid deglycase DJ-1
@en
prefLabel
Parkinsonism associated deglycase
@en
protéine deglycase DJ-1
@fr
P637
P638
P680
P681
P682
P705
P352
P486
P31
P352
P486
D000071617
P527
P637
NP_001116849
XP_005263481
P638
P680
P681
P682
P702
P703
P705
ENSP00000340278
ENSP00000366708
ENSP00000366711
ENSP00000418770
ENSP00000465404
ENSP00000466242
ENSP00000466756