DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
about
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityThe chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicityDJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageInteraction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathParkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residuesHuman DJ-1 and its homologs are novel glyoxalasesMitochondrial localization of DJ-1 leads to enhanced neuroprotectionDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionMolecules that cause or prevent Parkinson's diseaseSensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary ParkinsonismMitochondrial dysfunction in Parkinson's diseaseEvaluation of Models of Parkinson's DiseaseThe Tumorigenic Roles of the Cellular REDOX Regulatory SystemsThe associations between Parkinson's disease and cancer: the plot thickensStructural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1 † , ‡Cysteine p K a Depression by a Protonated Glutamic Acid in Human DJ-1 † ‡Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent MannerConservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetal-containing crystal structuresGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceCross Talk between Two Antioxidant Systems, Thioredoxin and DJ-1: Consequences for CancerEvidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell lineGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauAge-dependent motor deficits and dopaminergic dysfunction in DJ-1 null miceDJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidaseDJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE)Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injuryStructural effects of Parkinson's disease linked DJ-1 mutations.DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags.Genetic mouse models of parkinsonism: strengths and limitations.Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice.DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70.Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein.Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology
P2860
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P2860
DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@ast
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en-gb
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@nl
type
label
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@ast
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en-gb
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@nl
prefLabel
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@ast
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en-gb
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@nl
P2093
P2860
P921
P3181
P1433
P1476
DJ-1 is a redox-dependent mole ...... -synuclein aggregate formation
@en
P2093
Alan Jonason
Asa Abeliovich
Shoshana Shendelman
Thomas Leete
P2860
P356
10.1371/JOURNAL.PBIO.0020362
P407
P577
2004-10-05T00:00:00Z