P688
SIRT1 negatively regulates the mammalian target of rapamycinNegative control of p53 by Sir2alpha promotes cell survival under stresshSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseHuman Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repressionJNK1 phosphorylates SIRT1 and promotes its enzymatic activityComposition and histone substrates of polycomb repressive group complexes change during cellular differentiationSIRT1 regulates UV-induced DNA repair through deacetylating XPAModulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylationRepression of estrogen receptor beta function by putative tumor suppressor DBC1Sirt1 modulates premature senescence-like phenotype in human endothelial cellsRole of SIRT1 in homologous recombinationHuman SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasmPhosphorylation of HuR by Chk2 regulates SIRT1 expressionDynamic distribution of linker histone H1.5 in cellular differentiationInteractions between E2F1 and SirT1 regulate apoptotic response to DNA damageSIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formationAngiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cellsSIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cellsRegulation of unfolded protein response modulator XBP1s by acetylation and deacetylationSirtuin functions in health and diseaseSirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptorHuman SirT1 interacts with histone H1 and promotes formation of facultative heterochromatinMultiple tumor suppressor pathways negatively regulate telomeraseRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationStress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseEvolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteinsEpigenetic control of rDNA loci in response to intracellular energy statusThe deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophyRegulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum CA role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagySIRT1 regulates the function of the Nijmegen breakage syndrome proteinSIRT1 regulates circadian clock gene expression through PER2 deacetylationSirt1 deacetylates c-Myc and promotes c-Myc/Max associationHyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cellsSIRT1 deacetylates APE1 and regulates cellular base excision repairSIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
P921
Q50252296-19F8D344-A504-4C0E-A300-25D41654D886Q50252297-B69E1197-F3F7-4D85-B229-37C66C56F06FQ50258856-2E1BCAD7-AF2B-416F-9C06-7C0E89ECFFCDQ50286626-A9B01CAC-9059-4D0C-8329-245AFE4E0563Q50286627-C8D58EBE-9BB9-4A77-92B6-7B683D05F8F9Q50286628-F9F3325F-4770-4232-86D6-7100ACB49ED8Q50287086-0E008C98-A4AF-4804-9009-B1F2A8F90E51Q50287087-0F4574BE-3ED9-4AB0-B618-327F3836880EQ50290977-3492D9CA-10E1-4EA3-A83B-C27206066703Q50290980-AB950148-7108-4A20-9E40-AD1662483415
P527
Q21142655-5925F9D2-46DB-47A5-B4C6-CDDB0E9CF3FBQ24291828-DE030CD5-37B1-4C74-BFCA-505F4A57482AQ24291829-4E21DF9D-708E-4CB7-8212-85285F5E7181Q24292887-D6A1EA07-A124-4F0D-AFC1-CCB49F42C9A4Q24293117-EDDA947F-D326-4922-A6D3-6DEF27C4135FQ24293278-53243749-792F-4AD2-9901-65747F9FFB30Q24293574-E489840D-3FE3-411B-B36C-98AE25991B99Q24293656-B9A830C5-06B2-4A3C-8C85-29A762C9BCCFQ24293737-273D3043-8DB9-4E26-8AE6-F0133D243758Q24295117-9A67EE36-0911-4912-9762-8675FAB42A84Q24296492-576B7C95-1E56-4678-A59B-43ECD377B372Q24297067-F8CA3393-D7FF-454F-B054-16C7D00F5FD2Q24297146-98C23B3D-7DD1-4638-8E53-DFF9E6E5E62EQ24297333-0C1C810C-0989-4B3D-ADBD-44CEE5B8C315Q24297653-580EFA7A-5681-49BC-8EA3-58DCC189DF7BQ24297993-F33A8C50-71CB-4574-8F1C-9F52FF7DFC5AQ24298254-1D1F0878-085F-4C86-83D2-96B9700628C2Q24299098-9478655E-0236-41BB-A94D-CDD0CD4D3258Q24300487-5AD535BE-2455-4076-9D69-DD92AC01FD36Q24300671-DB36347F-684F-47C0-980E-AF4364649AB7Q24301693-7129BB7C-14EC-43F4-B545-44D48636CCB2Q24301843-BC48DB09-A22D-46D0-BAE1-67451C21CF7AQ24303825-3157DB09-A83E-4022-A00A-3583A7CAB0CFQ24303857-3D2D60AA-B267-4A64-90B9-9FF3584BD3D7Q24306066-1CA761D0-9D27-47C7-A664-092D842E72A5Q24306469-0F1FED06-8940-48DA-9589-F43B3955CE55Q24306608-5863424A-5B1A-40F6-A43D-17F67083C1B7Q24306868-DE883928-0D92-41E2-BA1E-DBF21C3F13DBQ24310456-AA21B695-3EB3-4612-BEBE-9F0E17CD6445Q24312912-1116184B-BBDF-4588-8A96-B0FAEB620785Q24313528-CE9C9088-FBCE-4F40-A153-44C2E52E8F7DQ24315832-AA4CAB96-E904-49F9-9BCE-B9CDC46F8B3FQ24315840-5B70D553-48D7-4941-BB7C-E7E39591035BQ24316492-A73A8464-90A6-47BB-91C2-2B766F7481E1Q24317230-C4EFF70D-638C-44C9-B122-E18364CA0084Q24317933-A03935DA-3E44-4171-990D-9368B75D3105Q24318556-75A22032-B2CC-4E9E-8DCE-7659105C2D72Q24319922-FCBCD1E0-8C55-4C4F-8184-D60E28DB747AQ24320136-330693E2-2458-4B90-A2AD-DDD9F9E8EC28Q24321658-C00BD48F-7CF2-42EA-8927-12EFEF1B3342
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Sirtuin 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
SIRT1
@es
SIRT1
@it
SIRT1
@uk
SIRT1
@zh
Sirtuin 1
@en
Sirtuin 1
@nl
Sirtuin-1
@de
Sirtuine 1
@fr
サーチュイン1
@ja
type
label
SIRT1
@es
SIRT1
@it
SIRT1
@uk
SIRT1
@zh
Sirtuin 1
@en
Sirtuin 1
@nl
Sirtuin-1
@de
Sirtuine 1
@fr
サーチュイン1
@ja
altLabel
NAD-dependent protein deacetylase sirtuin-1
@en
NAD-dependent protein deacylase sirtuin-1
@en
SIR2-like protein 1
@en
SIRT1
@en
hSIR2
@en
regulatory protein SIR2 homolog 1
@en
sirtuin type 1
@en
prefLabel
SIRT1
@es
SIRT1
@it
SIRT1
@uk
SIRT1
@zh
Sirtuin 1
@en
Sirtuin 1
@nl
Sirtuin-1
@de
Sirtuine 1
@fr
サーチュイン1
@ja
P361
P637
P638
P680
P681
P682
P705
P352
P486
P6366
P129
P31
P352
P361
P486
P6366
2776536020
P637
NP_001135970
NP_001300978
P638
P680
P681
P682
P702
P703
P705
ENSP00000212015
ENSP00000384063
ENSP00000384508
ENSP00000409208