Structure-guided recombination creates an artificial family of cytochromes P450.
about
Beyond directed evolution--semi-rational protein engineering and designExploring protein fitness landscapes by directed evolutionA family of thermostable fungal cellulases created by structure-guided recombinationSCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stabilityDiversification of catalytic function in a synthetic family of chimeric cytochrome p450sChimeragenesis of distantly-related proteins by noncontiguous recombinationStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationOlefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 EnzymesDesigning specific protein-protein interactions using computation, experimental library screening, or integrated methodsDirected evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks.SCHEMA computational design of virus capsid chimeras: calibrating how genome packaging, protection, and transduction correlate with calculated structural disruption.Non-homologous recombination of deoxyribonucleoside kinases from human and Drosophila melanogaster yields human-like enzymes with novel activities.Steering directed protein evolution: strategies to manage combinatorial complexity of mutant libraries.DNA shuffling of adeno-associated virus yields functionally diverse viral progenyOptimization of combinatorial mutagenesis.SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.Random field model reveals structure of the protein recombinational landscape.A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination.Recent Structural Insights into Cytochrome P450 Function.OptZyme: computational enzyme redesign using transition state analoguesA panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.Discriminating between stabilizing and destabilizing protein design mutations via recombination and simulation.Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsinsEngineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coliNavigating the protein fitness landscape with Gaussian processesP450(BM3) (CYP102A1): connecting the dots.Chimeric P450 enzymes: activity of artificial redox fusions driven by different reductases for biotechnological applications.Stabilizing biocatalysts.Engineering chimaeric proteins from fold fragments: 'hopeful monsters' in protein design.Recent advances in rational approaches for enzyme engineering.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Robust enzyme design: bioinformatic tools for improved protein stability.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Cytochrome P450 102A2 Catalyzes Efficient Oxidation of Sodium Dodecyl Sulphate: A Molecular Tool for Remediation.In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experimentsEngineering of human CYP3A enzymes by combination of activating polymorphic variants.The Iterative Protein Redesign and Optimization (IPRO) suite of programs.Screening for cytochrome p450 reactivity by harnessing catalase as reporter enzyme.
P2860
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P2860
Structure-guided recombination creates an artificial family of cytochromes P450.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structure-guided recombination creates an artificial family of cytochromes P450
@nl
Structure-guided recombination creates an artificial family of cytochromes P450.
@ast
Structure-guided recombination creates an artificial family of cytochromes P450.
@en
Structure-guided recombination creates an artificial family of cytochromes P450.
@en-gb
type
label
Structure-guided recombination creates an artificial family of cytochromes P450
@nl
Structure-guided recombination creates an artificial family of cytochromes P450.
@ast
Structure-guided recombination creates an artificial family of cytochromes P450.
@en
Structure-guided recombination creates an artificial family of cytochromes P450.
@en-gb
altLabel
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450
@en
prefLabel
Structure-guided recombination creates an artificial family of cytochromes P450
@nl
Structure-guided recombination creates an artificial family of cytochromes P450.
@ast
Structure-guided recombination creates an artificial family of cytochromes P450.
@en
Structure-guided recombination creates an artificial family of cytochromes P450.
@en-gb
P2093
P2860
P1433
P1476
Structure-guided recombination creates an artificial family of cytochromes P450.
@en
P2093
Christopher R Otey
Jeffrey B Endelman
Kaori Hiraga
Marco Landwehr
P2860
P356
10.1371/JOURNAL.PBIO.0040112
P407
P577
2006-04-11T00:00:00Z