about
P688
Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilinsPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyRelease of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADDPresenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activitiesMutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelinCell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCRProfiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamusMice lacking both presenilin genes exhibit early embryonic patterning defectsPresenilin 2 regulates the systolic function of heart by modulating Ca2+ signalingPresenilin 1 is required for maturation and cell surface accumulation of nicastrinA role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentForebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosisPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionEnvironment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient micePresenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 proteinPresenilins regulate alphabeta T cell development by modulating TCR signalingRequirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexPresenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brainLoss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegenerationNotch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somitesgamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesisSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockageCoordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneityPresenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover
P921
Q24301886-27F8CC7A-EE92-4B5F-A937-D26A38716994Q24672149-385AFA6A-729C-4C81-805D-8B9CA8787F79Q28206918-150267B0-BF88-416F-B7F2-77AC0EDA49B3Q28505078-5C6F5684-0198-411E-A67D-01646DCD2DACQ28506272-5B4B5E70-8401-4273-BA61-0F51F0E3ADD2Q28506461-DCA942D6-A816-4B82-B605-C34E7B80BAEBQ28507820-A09EA241-AE2B-486C-9CCE-C23DA4EC8922Q28508431-A3325FF1-EC02-4A09-A66B-D0948926E1A3Q28508716-6F167598-95D4-4B73-BBE6-9890637525B5Q28508946-5E3F6644-5CDF-4113-850C-4E1B0E60616AQ28509444-3AD13363-0A14-476F-AC92-9D26E198B0D7Q28510523-14BD5806-07C2-4984-AEC4-8C53646302CFQ28510710-BB5D33C0-8E5E-41AA-9EFB-7C43B71B193FQ28511413-D898B95A-EF8A-4BF4-8880-64678698CC30Q28512806-8E498D0D-1C05-44F4-BB52-1B440AFCE77DQ28585864-9CE4EBF6-42A0-4E6B-B166-D6B7AD6A4408Q28586083-523897B5-60C0-4D57-BC20-493B2DCAE895Q28586910-79D21760-EE51-49EB-90C4-0C38CAA50BE7Q28587481-2F25702F-C5E2-486A-A7E0-535D032AEA65Q28587555-EA70A8C6-B957-4E03-B2CF-7F3818B08E5BQ28588674-1F4520C7-6B23-446D-94D5-EF9625FC74B2Q28588759-C4F2D682-34DC-4E90-BA03-167186D04198Q28589919-613A1C5E-D3DC-4791-A289-8A2BA3446B29Q28590719-0BC518F2-1AF5-424B-BD99-3A2D4C65CD5BQ28590793-F73FB47F-69D2-41A4-9F8A-35FD924F0922Q28591384-500C30D0-CE0F-46E9-9128-06FD9D180416Q28591973-F903B283-2226-4A38-AA34-0C43B84E30F1Q28591999-CAB3172B-D798-494E-B5BB-194D3E3753B0Q28592098-FA2AB069-12FC-4ED4-92E8-E3883B9D4A96Q28594473-04DC8836-F846-4E38-9585-333726BF7697
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Presenilin 2
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Presenilin 2
@en
type
label
Presenilin 2
@en
altLabel
Psen2
@en
presenilin-2
@en
prefLabel
Presenilin 2
@en
P637
P680
P681
P682
P705
P352
P31
P352
P637
NP_001122077
XP_006496775
XP_011237078
P680
P681
P682
P702
P703
P705
ENSMUSP00000010753
ENSMUSP00000106733
ENSMUSP00000106734
ENSMUSP00000106735
ENSMUSP00000106737
ENSMUSP00000120216