Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseTargeting γ-secretase in breast cancerComplex regulation of γ-secretase: from obligatory to modulatory subunitsEvidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathwayΓ-secretase components as predictors of breast cancer outcomeRegulation of Alzheimer's disease amyloid-beta formation by casein kinase IPartial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexPresenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionThe canonical Notch signaling pathway: unfolding the activation mechanism.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesγ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide PeptidasePharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releaseDissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.Characterization of an atypical gamma-secretase complex from hematopoietic originA functional role for ADAM10 in human immunodeficiency virus type-1 replicationIncreased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.p53-dependent control of transactivation of the Pen2 promoter by presenilinsPresenilins: a novel link between intracellular calcium signaling and lysosomal function?Presenilin function and gamma-secretase activity.Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidInteractome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Substrate specificity of gamma-secretase and other intramembrane proteases.Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.Toward structural elucidation of the gamma-secretase complex.Intramembrane proteolysis by gamma-secretase.Signature amyloid β profiles are produced by different γ-secretase complexes.Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.The structure and function of Alzheimer's gamma secretase enzyme complex.
P2860
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P2860
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
description
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Juni 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/06/20)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/06/20)
@nl
наукова стаття, опублікована в червні 2003
@uk
name
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@ast
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@en
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@nl
type
label
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@ast
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@en
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@nl
prefLabel
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@ast
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@en
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@nl
P2093
P356
P1476
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
@en
P2093
Alan Bernstein
Daria Hazuda
Dorit B. Donoviel
Elizabeth Chen
Eric Price
Jillian DiMuzio-Mower
Ming-Chih Crouthamel
Ming-Tain Lai
Qian Huang
P304
22475–22481
P356
10.1074/JBC.M300974200
P407
P577
2003-06-20T00:00:00Z