Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage
about
Molecular characterization of a human DNA kinaseSpecific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNKComparative genomics and evolution of proteins involved in RNA metabolismInvolvement of human polynucleotide kinase in double-strand break repair by non-homologous end joiningGenome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomicsDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Mutations in PNKP cause microcephaly, seizures and defects in DNA repairHint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferasesPlant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic originsPathways for repairing and tolerating the spectrum of oxidative DNA lesionsDNA double-strand break repair pathway choice and cancerThe role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapyExpanding the ataxia with oculomotor apraxia type 4 phenotypeStructure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme.The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ PhosphataseUncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1).Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repairRepair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatasesProcessing of damaged DNA ends for double-strand break repair in mammalian cellsMutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathyXRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediatesThe structural basis of XRCC1-mediated DNA repairRole of polynucleotide kinase/phosphatase in mitochondrial DNA repairEnzymes involved in DNA ligation and end-healing in the radioresistant bacterium Deinococcus radiodurans.Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.Nonhomologous end joining: a good solution for bad endsStable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response.Repair of single-strand DNA interruptions by redundant pathways and its implication in cellular sensitivity to DNA-damaging agentsPol β associated complex and base excision repair factors in mouse fibroblasts.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsMammalian DNA single-strand break repair: an X-ra(y)ted affair.AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.Snail-mediated regulation of reactive oxygen species in ARCaP human prostate cancer cellsNeurological disorders associated with DNA strand-break processing enzymes.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiationRecognition and repair of chemically heterogeneous structures at DNA endsVariation in base excision repair capacity.
P2860
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P2860
Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Molecular cloning of the human ...... aks caused by oxidative damage
@ast
Molecular cloning of the human ...... aks caused by oxidative damage
@en
Molecular cloning of the human ...... aks caused by oxidative damage
@en-gb
Molecular cloning of the human ...... aks caused by oxidative damage
@nl
type
label
Molecular cloning of the human ...... aks caused by oxidative damage
@ast
Molecular cloning of the human ...... aks caused by oxidative damage
@en
Molecular cloning of the human ...... aks caused by oxidative damage
@en-gb
Molecular cloning of the human ...... aks caused by oxidative damage
@nl
prefLabel
Molecular cloning of the human ...... aks caused by oxidative damage
@ast
Molecular cloning of the human ...... aks caused by oxidative damage
@en
Molecular cloning of the human ...... aks caused by oxidative damage
@en-gb
Molecular cloning of the human ...... aks caused by oxidative damage
@nl
P2093
P2860
P3181
P356
P1476
Molecular cloning of the human ...... aks caused by oxidative damage
@en
P2093
S W Scherer
P2860
P304
P3181
P356
10.1074/JBC.274.34.24176
P407
P577
1999-08-20T00:00:00Z