about
Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damageConversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1Comparative genomics and evolution of proteins involved in RNA metabolismInvolvement of human polynucleotide kinase in double-strand break repair by non-homologous end joiningDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IVMutations in PNKP cause microcephaly, seizures and defects in DNA repairNEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cellsHint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferasesReal-time investigation of nucleic acids phosphorylation process using molecular beacons.The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapyExpanding the ataxia with oculomotor apraxia type 4 phenotypeStructure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme.Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1).Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatasesProcessing of damaged DNA ends for double-strand break repair in mammalian cellsXRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediatesRole of polynucleotide kinase/phosphatase in mitochondrial DNA repairMechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced gammaH2A.X FociMitochondrial DNA repair and association with aging--an updateSensing DNA damage by PARP-like fingers.Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitorsMammalian DNA single-strand break repair: an X-ra(y)ted affair.Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.Neurological disorders associated with DNA strand-break processing enzymes.A structural model for regulation of NHEJ by DNA-PKcs autophosphorylationVariation in base excision repair capacity.Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavageThe role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.Base excision repair in physiology and pathology of the central nervous systemRepair of topoisomerase I-mediated DNA damage.Oxidative DNA damage repair in mammalian cells: a new perspective.Brain capacity for repair of oxidatively damaged DNA and preservation of neuronal function.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Molecular characterization of a human DNA kinase
@ast
Molecular characterization of a human DNA kinase
@en
Molecular characterization of a human DNA kinase
@en-gb
Molecular characterization of a human DNA kinase
@nl
type
label
Molecular characterization of a human DNA kinase
@ast
Molecular characterization of a human DNA kinase
@en
Molecular characterization of a human DNA kinase
@en-gb
Molecular characterization of a human DNA kinase
@nl
prefLabel
Molecular characterization of a human DNA kinase
@ast
Molecular characterization of a human DNA kinase
@en
Molecular characterization of a human DNA kinase
@en-gb
Molecular characterization of a human DNA kinase
@nl
P2093
P2860
P356
P1476
Molecular characterization of a human DNA kinase
@en
P2093
D J Pappin
F Karimi-Busheri
G G Miller
M M Le Beau
M Weinfeld
P2860
P304
P356
10.1074/JBC.274.34.24187
P407
P577
1999-08-20T00:00:00Z