Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity
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Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancerAldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitisA novel polymorphism in the 17beta-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian menType 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularisRoles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniolTissue distribution of human AKR1C3 and rat homolog in the adult genitourinary systemCoherent expression chromosome cluster analysis reveals differential regulatory functions of amino-terminal and distal parathyroid hormone-related protein domains in prostate carcinomaStructure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenaseCrystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate CancercDNA cloning, expression and characterization of human prostaglandin F synthaseClose kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genesMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseA cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stressMethyl jasmonate: putative mechanisms of action on cancer cells cycle, metabolism, and apoptosisOverexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiationDifferential expression of type 2 3α/type 5 17β-hydroxysteroid dehydrogenase (AKR1C3) in tumors of the central nervous system.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor.The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma.Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism.AKR1C3 overexpression mediates methotrexate resistance in choriocarcinoma cellsSteroid hormone transforming aldo-keto reductases and cancer.Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence.Activities of aldo-keto reductase 1 enzymes on two inhaled corticosteroids: implications for the pharmacological effects of inhaled corticosteroidsSelective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate.Oxidative and reductive metabolism of lipid-peroxidation derived carbonyls.Role of aldo-keto reductase enzymes in mediating the timing of parturitionDevelopment of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases.Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma.Basal and Regulatory Promoter Studies of the AKR1C3 Gene in Relation to Prostate Cancer.A Role for the PPARgamma in Cancer Therapy.Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer.
P2860
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P2860
Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Identification of a principal ...... n D2 11-ketoreductase activity
@ast
Identification of a principal ...... n D2 11-ketoreductase activity
@en
Identification of a principal ...... n D2 11-ketoreductase activity
@en-gb
Identification of a principal ...... n D2 11-ketoreductase activity
@nl
type
label
Identification of a principal ...... n D2 11-ketoreductase activity
@ast
Identification of a principal ...... n D2 11-ketoreductase activity
@en
Identification of a principal ...... n D2 11-ketoreductase activity
@en-gb
Identification of a principal ...... n D2 11-ketoreductase activity
@nl
prefLabel
Identification of a principal ...... n D2 11-ketoreductase activity
@ast
Identification of a principal ...... n D2 11-ketoreductase activity
@en
Identification of a principal ...... n D2 11-ketoreductase activity
@en-gb
Identification of a principal ...... n D2 11-ketoreductase activity
@nl
P2093
P3181
P1476
Identification of a principal ...... n D2 11-ketoreductase activity
@en
P2093
H Shiraishi
K Matsuura
M Ninomiya
Y Deyashiki
P3181
P356
10.1093/OXFORDJOURNALS.JBCHEM.A022211
P407
P577
1998-11-01T00:00:00Z