Steroid hormone transforming aldo-keto reductases and cancer. - sprookjes - yvandenbroek - TriplyDB

Steroid hormone transforming aldo-keto reductases and cancer.

Steroid hormone transforming aldo-keto reductases and cancer.

http://www.wikidata.org/entity/Q34571239

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Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily Androgen Receptor: A Complex Therapeutic Target for Breast Cancer The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes.The CCAAT box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 (AKR1C1) gene Dimethylarginine dimethylaminohydrolase 2, a newly identified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes.Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism.Analysis of lead toxicity in human cells Pharmacologic inhibition of Jak2-Stat5 signaling By Jak2 inhibitor AZD1480 potently suppresses growth of both primary and castrate-resistant prostate cancer.Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia Development of selective androgen receptor modulators (SARMs).Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis.Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3).Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer.Identification of miR-193b targets in breast cancer cells and systems biological analysis of their functional impact Quantitative evaluation of aldo-keto reductase expression in hepatocellular carcinoma (HCC) cell lines.Methyljasmonate displays in vitro and in vivo activity against multiple myeloma cells.Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling.MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor STAT5A/B gene locus undergoes amplification during human prostate cancer progression.Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors.The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes.TGFβ1 alters androgenic metabolites and hydroxysteroid dehydrogenase enzyme expression in human prostate reactive stromal primary cells: Is steroid metabolism altered by prostate reactive stromal microenvironment?Steroid hormone metabolizing enzymes in benign and malignant human bone tumors.Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles.Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.New agents and strategies for the hormonal treatment of castration-resistant prostate cancer.Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily.Regulation of aldo-keto reductases in human diseases.The anti-cancer activities of jasmonates.

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P2860

Steroid hormone transforming aldo-keto reductases and cancer.

http://www.wikidata.org/entity/Q34571239

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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Steroid hormone transforming aldo-keto reductases and cancer.

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J.1749-6632.2009.03700.X

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Annals of the New York Academy of Sciences

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Steroid hormone transforming aldo-keto reductases and cancer.

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P2093

Michael C Byrns

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Trevor M Penning

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P2860

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate

Crystal structure of human prostaglandin F synthase (AKR1C3)

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency

The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases

Comparative anatomy of the aldo-keto reductase superfamily

Immunoelectron microscopic localization of 3beta-hydroxysteroid dehydrogenase and type 5 17beta-hydroxysteroid dehydrogenase in the human prostate and mammary gland.

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10.1111/J.1749-6632.2009.03700.X

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