Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
about
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndromeThe X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activationStructural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cellsNTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative diseaseX-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cellsThe X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa BCytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccinesFine specificity and molecular competition in SLAM family receptor signallingmSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functionsUp on the tightrope: natural killer cell activation and inhibitionNK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation.Ribosomal and immune transcripts associate with relapse in acquired ADAMTS13-deficient thrombotic thrombocytopenic purpuraCD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling.Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.Signaling activities of gammaherpesvirus membrane proteinsAbsence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis.Turning on natural killer cells.Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes.Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors.SLAM Family Receptors Regulate Immunity with and without SAP-related AdaptorsAltered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAPNatural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts.An ENU mutagenesis approach to dissect "self"-induced immune responses: Unraveling the genetic footprint of immunosurveillance.2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals.A role for SHIP in stem cell biology and transplantation.Inhibitory receptors on lymphocytes: insights from infections2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans.Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells.2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness.Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2.The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1Glycosylation affects ligand binding and function of the activating natural killer cell receptor 2B4 (CD244) protein.NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.Protein kinase C is involved in 2B4 (CD244)-mediated cytotoxicity and AP-1 activation in natural killer cells.
P2860
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P2860
Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
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1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@ast
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en-gb
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@nl
type
label
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@ast
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en-gb
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@nl
prefLabel
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@ast
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en-gb
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@nl
P2093
P3181
P1476
Cutting edge: human 2B4, an ac ...... adaptor signaling protein SAP
@en
P2093
E Woollatt
G R Sutherland
J H Phillips
L L Lanier
S G Tangye
P304
P3181
P407
P577
1999-06-15T00:00:00Z