2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells. - sprookjes - yvandenbroek - TriplyDB

2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.

2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.

http://www.wikidata.org/entity/Q36399476

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Responses to Microbial Challenges by SLAMF Receptors Structure of Natural Killer Receptor 2B4 Bound to CD48 Reveals Basis for Heterophilic Recognition in Signaling Lymphocyte Activation Molecule Family Structure of Natural Killer Cell Receptor KLRG1 Bound to E-Cadherin Reveals Basis for MHC-Independent Missing Self Recognition Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function CD244 is expressed on dendritic cells and regulates their functions Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions Up on the tightrope: natural killer cell activation and inhibition SLAM-family receptors: immune regulators with or without SAP-family adaptors.Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis.TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence Oncogenic stress sensed by the immune system: role of natural killer cell receptors Recognition of tumors by the innate immune system and natural killer cells.Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells NK cells and their ability to modulate T cells during virus infections Involvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis.2B4+ CD8+ T cells play an inhibitory role against constrained HIV epitopes.The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition.2B4 inhibits NK-cell fratricide.Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.A new self: MHC-class-I-independent natural-killer-cell self-tolerance.IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus.Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2 Inhibition of immune responses by ITAM-bearing receptors.SH2D1A regulates T-dependent humoral autoimmunity.Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.Immune regulation by SLAM family receptors and SAP-related adaptors.Evolving role of 2B4/CD244 in T and NK cell responses during virus infection.NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections.NK cell regulation by SLAM family receptors and SAP-related adapters.Activation, coactivation, and costimulation of resting human natural killer cells Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.Licensing of natural killer cells by self-major histocompatibility complex class I.Roles of CD48 in regulating immunity and tolerance.

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P2860

2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.

http://www.wikidata.org/entity/Q36399476

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2004 nî lūn-bûn

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2B4 acts as a non-major histoc ...... on mouse natural killer cells.

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2B4 acts as a non-major histoc ...... on mouse natural killer cells.

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Journal of Experimental Medicine

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2B4 acts as a non-major histoc ...... on mouse natural killer cells.

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John D Schatzle

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Kyung-Mi Lee

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Megan E McNerney

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Michael Bennett

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Porunelloor A Mathew

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Susan E Stepp

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Vinay Kumar

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P2860

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP

Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation.

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells

X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

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1245-1254

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10.1084/JEM.20031989

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9

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199

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15123744

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2211902

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