APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl
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Kinase activation through dimerization by human SH2-BThe adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-KitSH2-B is required for both male and female reproductionEnhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkAutophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activityTyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B betaRegulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor proteinIncreased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domainsPhysical and functional interactions between STAP-2/BKS and STAT5.The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.SH2B1 regulation of energy balance, body weight, and glucose metabolism.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasmsLnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FNucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genesControl of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active stateThe role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders.Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain.Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome.The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor.A phenylalanine zipper mediates APS dimerization.Phosphorylation of the Unique C-terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1alpha to Enhance Nerve Growth Factor Function.Phosphorylation of APS
P2860
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P2860
APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@ast
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en-gb
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@nl
type
label
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@ast
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en-gb
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@nl
prefLabel
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@ast
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en-gb
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@nl
P2093
P356
P1433
P1476
APS, an adaptor protein contai ...... ay in collaboration with c-Cbl
@en
P2093
A Yoshimura
M Yokouchi
P2888
P356
10.1038/SJ.LEU.2401397
P407
P577
1999-05-01T00:00:00Z
P5875
P6179
1026152521