IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
about
Plant and animal pathogen recognition receptors signal through non-RD kinasesIRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stabilityDifferential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signalingDistinct molecular mechanism for initiating TRAF6 signallingCharacterization of Pellino2, a substrate of IRAK1 and IRAK4IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine productionPellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complexIRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinaseInterleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathwayIRAK-M is involved in the pathogenesis of early-onset persistent asthmaNoncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammationIL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy ResistanceThe TLR and IL-1 signalling network at a glanceIRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pyloriStructure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding SiteTIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signalingIdentification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signalingSevere impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4IRAK-4 inhibitors for inflammationMycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophagesSignal transduction by the lipopolysaccharide receptor, Toll-like receptor-4Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signalingInterleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNAThe role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signalingThe murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitoryInhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4Negative regulation of toll-like receptor-mediated immune responsesStructural dynamic analysis of apo and ATP-bound IRAK4 kinaseThreonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation.Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-κB activity through promoting TRAF6 ubiquitinationInduction and termination of inflammatory signaling in group B streptococcal sepsis.IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis.Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences.Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice.A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning.Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-MDifferential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis.
P2860
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
P248
Q21131622-D43CEE6F-9013-4950-BE08-8525CFD0E00EQ24291311-5452B0AD-2E98-44F0-AB15-C378AD2BC596Q24300680-E483D0FB-F9BE-4295-8359-2D9B590CC0DFQ24302174-D620409E-056B-4B92-BC3A-58B12BB0FF5CQ24308089-C73194A8-26C7-4BFC-A93F-8FBE96618D72Q24313305-FB21CF55-F027-4DD7-8578-B296E7B7EC9EQ24337456-346E295C-85CF-4A40-9412-E41882460C7EQ24534145-248A6322-38CD-46F2-8F93-E3A5C8F8A7E4Q24550984-56BA97CD-FBD8-4E73-9BB5-92376E51DD06Q24670024-A376CBE8-7F4E-42CA-AE6E-B39B8BAFB14DQ26865593-2198CA42-50BB-405A-8B01-B710C454B754Q26866390-44216C27-BAF3-48B0-8BD4-1BE61722E8B3Q27013358-94A15D0E-1FF5-442E-B48C-30C5F267C103Q27313540-38B5E2BB-EFEA-425E-95B5-334AE756D6A5Q27653415-869A2C14-9886-4BB4-A1FE-40E4E2E90C76Q28201815-F376F32C-3B9C-40D5-A650-7B2CCA3BC455Q28207396-C5A57348-A8A2-498C-95FD-C25194B7DA93Q28211574-06D2B164-4567-42A6-98F9-6D7CEABCE88CQ28255508-347EA999-F357-49DC-922E-DFA8C7B87E84Q28279932-5CBF054A-6496-473E-AD4B-AB8DE2AEA013Q28283196-89710A81-B9AA-4F56-B351-C34F1D21951CQ28301000-B74A76A7-1C65-457A-A950-D8DE129621EAQ28482485-3C91E5B8-79FB-4EB1-817F-9440CAD82B7CQ28586254-69CD2D4E-700C-4C66-9556-F26636F3BA02Q28586277-57E93548-C6E4-48F9-B1A2-EEC596164067Q28611075-9E4F0B35-ED66-4536-ACD4-64485734E55BQ29619019-4262602E-6AE7-44A0-BB0E-68FE779D462AQ30584224-2BA22D38-04F7-4ABA-962F-7BEB4A7A9936Q33340474-792D0138-AC4A-414D-96AA-E72710A28030Q33556138-C5D18FF8-8DCD-4A45-AF26-6DF2C21296E9Q33608933-5579619F-78DA-4D48-BC1C-0A1616FA78FEQ33618905-CCB3E72C-6255-44BE-B7FB-1D75E1B3B134Q33762394-3980E9CC-FF50-469A-9A33-3F1DA8AA2764Q33889702-3FB49A88-519A-4217-BAB9-8400E6CCC6CBQ33959795-AD3903FC-404F-47BF-AD74-499288669BB2Q34044755-9E5D2EE7-0027-4489-87F4-D1C41BDF4FA3Q34107371-1F205926-2DC0-4EB5-8047-4C6663034233Q34137738-017FF860-D6A1-416C-BF46-1AE40BDA8257Q34151363-AC783416-F31E-4083-A843-B3138AAB6DAFQ34168594-43A63B7D-CA30-469E-89B0-4F7ADA54363C
P2860
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@ast
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en-gb
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@nl
type
label
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@ast
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en-gb
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@nl
prefLabel
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@ast
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en-gb
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@nl
P2093
P2860
P921
P3181
P356
P1476
IRAK-M is a novel member of th ...... ssociated kinase (IRAK) family
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.274.27.19403
P407
P577
1999-07-02T00:00:00Z