In the light of directed evolution: pathways of adaptive protein evolution
about
Evolution of minimal specificity and promiscuity in steroid hormone receptorsDirected evolution of bright mutants of an oxygen-independent flavin-binding fluorescent protein from Pseudomonas putidaEvolutionary origin of a secondary structure: π-helices as cryptic but widespread insertional variations of α-helices that enhance protein functionalityEngineering of TEV protease variants by yeast ER sequestration screening (YESS) of combinatorial librariesExploring protein fitness landscapes by directed evolutionMetalloprotein-based MRI probesToxicological evaluation of proteins introduced into food cropsSelective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenaseStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceTowards a restriction proteinase: construction of a self-activating enzymeMechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid ReceptorEnhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolutionBiocatalytic and structural properties of a highly engineered halohydrin dehalogenaseDirected divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substratesEnvironmental changes bridge evolutionary valleysDirected evolution: tailoring biocatalysts for industrial applicationsAnalyzing protein structure and function using ancestral gene reconstructionPrevalence of epistasis in the evolution of influenza A surface proteinsNetwork models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectoriesHigh-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networksNatural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme StabilityStrong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a ProteinPredicting the tolerated sequences for proteins and protein interfaces using RosettaBackrub flexible backbone designThermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designedTracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptorViewing protein fitness landscapes through a next-gen lens.The virtue of innovation: innovation through the lenses of biological evolutionEvolutionary fates within a microbial population highlight an essential role for protein folding during natural selection.Disease risk of missense mutations using structural inference from predicted functionDynamic New World: Refining Our View of Protein Structure, Function and EvolutionA practical teaching course in directed protein evolution using the green fluorescent protein as a model.Stabilization of a metabolic enzyme by library selection in Thermus thermophilus.Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus.Strategy for directing combinatorial genome engineering in Escherichia coli.Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.Evolving thermostability in mutant libraries of ligninolytic oxidoreductases expressed in yeast.Protein evolution via amino acid and codon elimination.Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Capturing, sharing and analysing biophysical data from protein engineering and protein characterization studies.Metal ions as matchmakers for proteins.
P2860
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P2860
In the light of directed evolution: pathways of adaptive protein evolution
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
In the light of directed evolution: pathways of adaptive protein evolution
@ast
In the light of directed evolution: pathways of adaptive protein evolution
@en
In the light of directed evolution: pathways of adaptive protein evolution
@nl
type
label
In the light of directed evolution: pathways of adaptive protein evolution
@ast
In the light of directed evolution: pathways of adaptive protein evolution
@en
In the light of directed evolution: pathways of adaptive protein evolution
@nl
prefLabel
In the light of directed evolution: pathways of adaptive protein evolution
@ast
In the light of directed evolution: pathways of adaptive protein evolution
@en
In the light of directed evolution: pathways of adaptive protein evolution
@nl
P2860
P3181
P356
P1476
In the light of directed evolution: pathways of adaptive protein evolution
@en
P2860
P304
9995-10000
P3181
P356
10.1073/PNAS.0901522106
P407
P433
Supplement_1
P478
106 Suppl 1
P577
2009-06-16T00:00:00Z