about
Stability-mediated epistasis constrains the evolution of an influenza proteinEvolution favors protein mutational robustness in sufficiently large populationsEVOLUTION OF EVOLVABILITY IN A DEVELOPMENTAL MODELMutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studiesEvolution of molecular error rates and the consequences for evolvability.In the light of directed evolution: pathways of adaptive protein evolutionThe frailty of adaptive hypotheses for the origins of organismal complexityMutational robustness can facilitate adaptationExploring protein fitness landscapes by directed evolutionRobustness and evolvabilityRobustness: mechanisms and consequencesRobustness and evolvability: a paradox resolvedCrystal structure of an ancient protein: evolution by conformational epistasisHigh-throughput thermal scanning: a general, rapid dye-binding thermal shift screen for protein engineeringConsensus protein designEngineered IgG1-Fc--one fragment to bind them allProtein stability: computation, sequence statistics, and new experimental methodsTargeted metagenomics unveils the molecular basis for adaptive evolution of enzymes to their environmentApproaches to engineer stability of beetle luciferasesThe role of robustness in phenotypic adaptation and innovationAdaptive protein evolution grants organismal fitness by improving catalysis and flexibilityFollowing evolutionary paths to protein-protein interactions with high affinity and selectivityStructural Bases for Stability–Function Tradeoffs in Antibiotic ResistanceMechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid ReceptorStructure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanolThe Molecular Basis for the Broad Substrate Specificity of Human Sulfotransferase 1A1A Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Nonnatural ReactionGeneral approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADHKey Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate BiasStructure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and SerotoninTracing Primordial Protein Evolution through Structurally Guided Stepwise Segment ElongationBridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme StabilizationImproving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed EvolutionEngineering protein thermostability using a generic activity-independent biophysical screen inside the cellDirected divergent evolution of a thermostable D-tagatose epimerase towards improved activity for two hexose substratesDirected evolution of a pyruvate aldolase to recognize a long chain acyl substrateThermodynamics of neutral protein evolutionAnalyzing protein structure and function using ancestral gene reconstructionThermostabilization of an esterase by alignment-guided focussed directed evolution
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Protein stability promotes evolvability
@ast
Protein stability promotes evolvability
@en
Protein stability promotes evolvability
@nl
type
label
Protein stability promotes evolvability
@ast
Protein stability promotes evolvability
@en
Protein stability promotes evolvability
@nl
prefLabel
Protein stability promotes evolvability
@ast
Protein stability promotes evolvability
@en
Protein stability promotes evolvability
@nl
P2860
P3181
P356
P1476
Protein stability promotes evolvability
@en
P2093
Christopher R Otey
Sy T Labthavikul
P2860
P304
P3181
P356
10.1073/PNAS.0510098103
P407
P577
2006-04-11T00:00:00Z