Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
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Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivoRBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrestTargeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcriptionInhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motifConserved and specific functions of mammalian ssu72Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein ArchitectureAPC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathwayTwo new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferationMolecular determinants for the complex formation between the retinoblastoma protein and LXCXE sequencesSV40 large T antigen targets multiple cellular pathways to elicit cellular transformationSeparation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain.The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.Human herpesvirus 6A (HHV-6A) and HHV-6B alter E2F1/Rb pathways and E2F1 localization and cause cell cycle arrest in infected T cellsLoss of the mammalian DREAM complex deregulates chondrocyte proliferationCritical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesisExamination of the pRb-dependent and pRb-independent functions of E7 in vivo.Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressiveCDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers.Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle.DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.Rb-mediated chromatin structure regulation and transcriptional repression.Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products.The B-domain lysine patch of pRB is required for binding to large T antigen and release of E2F by phosphorylationThree regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor.Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cellsBiological activities and molecular targets of the human papillomavirus E7 oncoprotein.The retinoblastoma protein regulates pericentric heterochromatin.Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor.Clefts, grooves, and (small) pockets: the structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled.E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor.pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth.
P2860
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P2860
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@ast
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en-gb
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@nl
type
label
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@ast
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en-gb
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@nl
prefLabel
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@ast
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en-gb
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@nl
P2093
P2860
P3181
P1476
Mutagenesis of the pRB pocket ...... binding to viral oncoproteins
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.20.10.3715-3727.2000
P407
P577
2000-05-01T00:00:00Z