Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function
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Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selectionExpression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutationsImportance of glutamate 279 for the coenzyme binding of human glutamate dehydrogenaseGain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onsetHuman GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cellsThe discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and diseaseMultiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological ImplicationsColloquium paper: phylogenomic evidence of adaptive evolution in the ancestry of humansTransgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.Glutamate metabolism and HIV-associated neurocognitive disorders.Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.Leucine metabolism in regulation of insulin secretion from pancreatic beta cells.Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain.Involvement of GDH3-encoded NADP+-dependent glutamate dehydrogenase in yeast cell resistance to stress-induced apoptosis in stationary phase cellsGenetic basis of human brain evolutionThe Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?Glutamate dehydrogenases: the why and how of coenzyme specificity.The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase.Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.Purification of glutamate dehydrogenase from liver and brain.Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA.Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. An essential residue in catalysis.Identification of the GTP binding site of human glutamate dehydrogenase by cassette mutagenesis and photoaffinity labeling.Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex.Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.Expression of the human isoform of glutamate dehydrogenase, hGDH2, augments TCA cycle capacity and oxidative metabolism of glutamate during glucose deprivation in astrocytes.Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.Enzyme Complexes Important for the Glutamate-Glutamine Cycle.Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes
P2860
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P2860
Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function
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2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@ast
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en-gb
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@nl
type
label
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@ast
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en-gb
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@nl
prefLabel
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@ast
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en-gb
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@nl
P2093
P2860
P921
P1476
Nerve tissue-specific (GLUD2) ...... ications for biologic function
@en
P2093
A Plaitakis
M Metaxari
P Shashidharan
P2860
P304
P356
10.1046/J.1471-4159.2000.0751862.X
P407
P577
2000-11-01T00:00:00Z