Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. - sprookjes - yvandenbroek - TriplyDB

Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.

Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.

http://www.wikidata.org/entity/Q30437305

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Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin-proteasome systems Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS.Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction Ischemic tolerance in an in vivo model of glutamate preconditioning.Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice Elevated GFAP induces astrocyte dysfunction in caudal brain regions: A potential mechanism for hindbrain involved symptoms in type II Alexander disease.Selective neuronal vulnerability of human hippocampal CA1 neurons: lesion evolution, temporal course, and pattern of hippocampal damage in diffusion-weighted MR imaging.Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.Import of a major mitochondrial enzyme depends on synergy between two distinct helices of its presequence.Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging Time-Dependent Compensatory Responses to Chronic Neuroinflammation in Hippocampus and Brainstem: The Potential Role of Glutamate Neurotransmission The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?Deregulation of glutamate dehydrogenase in human neurologic disorders.Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues.Electrochemical techniques for subsecond neurotransmitter detection in live rodents.Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo.Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia.Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression.Deletion of neuronal gap junction protein connexin 36 impairs hippocampal LTP.Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point.Enzyme Complexes Important for the Glutamate-Glutamine Cycle.Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons.Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration.

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Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.

http://www.wikidata.org/entity/Q30437305

description

2009 nî lūn-bûn

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2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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JNEUROSCI.4413-09.2009

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Journal of Neuroscience

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Transgenic expression of Glud1 ...... ective neuronal vulnerability.

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P2093

Abdulbaki Agbas

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Andrei B Belousov

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Dongwei Hui

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Elias K Michaelis

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Greg A Gerhardt

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In-Young Choi

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Kevin N Hascup

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Mary L Michaelis

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Ranu Pal

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Wen-Tung Wang

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P2860

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function

Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene

Aggresomes: a cellular response to misfolded proteins

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

Structural basis of long-term potentiation in single dendritic spines

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines.

Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices.

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13929-13944

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10.1523/JNEUROSCI.4413-09.2009

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