The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
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PinX1 suppresses bladder urothelial carcinoma cell proliferation via the inhibition of telomerase activity and p16/cyclin D1 pathwayInvolvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindleThe F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenanceTargeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2PTOP interacts with POT1 and regulates its localization to telomeresRap1 affects the length and heterogeneity of human telomeresA critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyCharacterization of interactions between PinX1 and human telomerase subunits hTERT and hTRTelosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsThe human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activityTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationPinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual rolesIncreased Stability of Nucleolar PinX1 in the Presence of TERTHuman telomerase and its regulationShelterin complex and associated factors at human telomeresFamily Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis.A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteinsTherapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.Conserved interactions of the splicing factor Ntr1/Spp382 with proteins involved in DNA double-strand break repair and telomere metabolism.Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNAThe telomerase inhibitor Gno1p/PINX1 activates the helicase Prp43p during ribosome biogenesis.The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition.Telomerase Regulation from Beginning to the EndTelomerase as a Cancer Target. Development of New MoleculesHuman Ku70/80 associates physically with telomerase through interaction with hTERTDNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptaseGeneration and characterization of telomere length maintenance in tankyrase 2-deficient mice.Identification and Characterization of a Novel Issatchenkia orientalis GPI-Anchored Protein, IoGas1, Required for Resistance to Low pH and Salt StressNEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradationThe Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.Expression of the telomeric repeat binding factor gene NgTRF1 is closely coordinated with the cell division program in tobacco BY-2 suspension culture cells.Natural and pharmacological regulation of telomeraseIncreased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosisComputationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).Reduced expression of PinX1 correlates to progressive features in patients with prostate cancer.The biogenesis and regulation of telomerase holoenzymesOver-expression of LPTS-L in hepatocellular carcinoma cell line SMMC-7721 induces crisis.
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P2860
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
description
2001 nî lūn-bûn
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2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年学术文章
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2001年學術文章
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name
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@ast
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en-gb
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
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type
label
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@ast
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en-gb
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@nl
prefLabel
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@ast
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en-gb
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@nl
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The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
@en
P304
P3181
P356
10.1016/S0092-8674(01)00538-4
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P577
2001-11-02T00:00:00Z