Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
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TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complexVault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivoRap1 affects the length and heterogeneity of human telomeresPOT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complexTelomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongationIn vivo stoichiometry of shelterin componentsPinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual rolesHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroHuman telomerase and its regulationBRCA1 inhibition of telomerase activity in cultured cellsUp-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesisTelomere rapid deletion regulates telomere length in Arabidopsis thalianaA balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytesSLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with TelomeresSubtelomeric proteins negatively regulate telomere elongation in budding yeast.MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresTRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeresTankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and cappingNuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.Dynamics of protein binding to telomeres in living cells: implications for telomere structure and function.Genome comparison of human and non-human malaria parasites reveals species subset-specific genes potentially linked to human disease.The individual blood cell telomere attrition rate is telomere length dependentComputationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in malesCrosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeresTelomere length homeostasis requires that telomerase levels are limiting.Telomere maintenance mechanisms in cancer: clinical implicationsCoordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomasTelomere length modulation in human astroglial brain tumorsInterleukin-6 decreases senescence and increases telomerase activity in malignant human cholangiocytes.The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms.Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in miceDefective repair of uracil causes telomere defects in mouse hematopoietic cells.Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cellsPinX1: a sought-after major tumor suppressor at human chromosome 8p23Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
P2860
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P2860
Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Targeting assay to study the c ...... f telomere degradation by TRF2
@ast
Targeting assay to study the c ...... f telomere degradation by TRF2
@en
Targeting assay to study the c ...... f telomere degradation by TRF2
@en-gb
Targeting assay to study the c ...... f telomere degradation by TRF2
@nl
type
label
Targeting assay to study the c ...... f telomere degradation by TRF2
@ast
Targeting assay to study the c ...... f telomere degradation by TRF2
@en
Targeting assay to study the c ...... f telomere degradation by TRF2
@en-gb
Targeting assay to study the c ...... f telomere degradation by TRF2
@nl
altLabel
Targeting Assay To Study the c ...... f Telomere Degradation by TRF2
@en
Targeting Assay To Study the c ...... f Telomere Degradation by TRF2
@nl
prefLabel
Targeting assay to study the c ...... f telomere degradation by TRF2
@ast
Targeting assay to study the c ...... f telomere degradation by TRF2
@en
Targeting assay to study the c ...... f telomere degradation by TRF2
@en-gb
Targeting assay to study the c ...... f telomere degradation by TRF2
@nl
P2093
P2860
P921
P3181
P1476
Targeting Assay To Study the c ...... f Telomere Degradation by TRF2
@en
Targeting assay to study the c ...... f telomere degradation by TRF2
@en
P2093
C.-E. Koering
Catherine-Elaine Koering
Christine Brun
Eric Gilson
J.-P. Pommier
Jean-Patrick Pommier
K. Ancelin
L. Sabatier
P2860
P304
P3181
P356
10.1128/MCB.22.10.3474-3487.2002
P407
P577
2002-05-01T00:00:00Z
2002-05-15T00:00:00Z