Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently
about
J protein mutations and resulting proteostasis collapseBreast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperoneMutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophyThe DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptidesThe DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitmentStructural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental developmentImpaired placental trophoblast lineage differentiation in Alkbh1(-/-) miceThe HSP70 chaperone machinery: J proteins as drivers of functional specificityHeat shock proteins: cellular and molecular mechanisms in the central nervous system.Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophyDNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants.Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin.Micro-RNA-632 downregulates DNAJB6 in breast cancer.A Hsp40 chaperone protein interacts with and modulates the cellular distribution of the primase protein of human cytomegalovirus.Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases.Exome sequencing reveals DNAJB6 mutations in dominantly-inherited myopathy.Meeting Report: New Directions in the Biology and Disease of Skeletal Muscle 2014Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafishSpecific protein homeostatic functions of small heat-shock proteins increase lifespan.A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy.Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer.DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontinA modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios.A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.Hsp70 protein complexes as drug targets.Genetic basis of limb-girdle muscular dystrophies: the 2014 updateThe molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.Emerging roles and underlying molecular mechanisms of DNAJB6 in cancerOverexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway.Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin.Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein.Comparative gene expression profiling of human metallothionein-3 up-regulation in neuroblastoma cells and its impact on susceptibility to cisplatin.
P2860
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P2860
Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Characterization of a brain-en ...... ion and toxicity independently
@ast
Characterization of a brain-en ...... ion and toxicity independently
@en
Characterization of a brain-en ...... ion and toxicity independently
@en-gb
Characterization of a brain-en ...... ion and toxicity independently
@nl
type
label
Characterization of a brain-en ...... ion and toxicity independently
@ast
Characterization of a brain-en ...... ion and toxicity independently
@en
Characterization of a brain-en ...... ion and toxicity independently
@en-gb
Characterization of a brain-en ...... ion and toxicity independently
@nl
prefLabel
Characterization of a brain-en ...... ion and toxicity independently
@ast
Characterization of a brain-en ...... ion and toxicity independently
@en
Characterization of a brain-en ...... ion and toxicity independently
@en-gb
Characterization of a brain-en ...... ion and toxicity independently
@nl
P2093
P2860
P921
P3181
P356
P1476
Characterization of a brain-en ...... ion and toxicity independently
@en
P2093
Ching-Hwa Sung
Jen-Zen Chuang
Meicai Zhu
Shi-Hua Li
Xiao-Jiang Li
P2860
P304
P3181
P356
10.1074/JBC.M109613200
P407
P577
2002-05-31T00:00:00Z