Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
about
Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotypeThe RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membraneStructural basis for Rab GTPase activation by VPS9 domain exchange factorsSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerCatalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Raf family kinases: old dogs have learned new tricksActivation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activationA structure-based benchmark for protein-protein binding affinitySpecificity in Ras and Rap signalingUnusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesRegulation of small GTPases by GEFs, GAPs, and GDIsRegulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activationRational design of small molecule inhibitors targeting the Ras GEF, SOS1.Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueStructural Basis and Mechanism of Autoregulation in 3-Phosphoinositide-Dependent Grp1 Family Arf GTPase Exchange FactorsOn the significance of Toc-GTPase homodimersRole of the histone domain in the autoinhibition and activation of the Ras activator Son of SevenlessActivated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for AutoregulationCoupling of receptor conformation and ligand orientation determine graded activityStructural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1aNSP-Cas protein structures reveal a promiscuous interaction module in cell signalingIn silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interactionSmall-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activityIntegrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2A Novel Membrane Sensor Controls the Localization and ArfGEF Activity of Bacterial RalFApproach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Germline gain-of-function mutations in SOS1 cause Noonan syndromeNovel peptides from the RAS-p21 and p53 proteins for the treatment of cancerDifferences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1A Ras-induced conformational switch in the Ras activator Son of sevenlessCollybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.Structure-based inhibition of protein-protein interactions.Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains.Single molecule tracking on supported membranes with arrays of optical nanoantennas.Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals.One-way membrane trafficking of SOS in receptor-triggered Ras activation.
P2860
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P2860
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural evidence for feedba ...... nucleotide exchange factor SOS
@ast
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en-gb
Structural evidence for feedba ...... nucleotide exchange factor SOS
@nl
type
label
Structural evidence for feedba ...... nucleotide exchange factor SOS
@ast
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en-gb
Structural evidence for feedba ...... nucleotide exchange factor SOS
@nl
prefLabel
Structural evidence for feedba ...... nucleotide exchange factor SOS
@ast
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en-gb
Structural evidence for feedba ...... nucleotide exchange factor SOS
@nl
P2093
P50
P3181
P1433
P1476
Structural evidence for feedba ...... nucleotide exchange factor SOS
@en
P2093
Andre Hoelz
Bhushan Nagar
Brian E Hall
S Mariana Margarit
P304
P3181
P356
10.1016/S0092-8674(03)00149-1
P407
P577
2003-03-07T00:00:00Z