The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
about
An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in miceRadixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationG protein betagamma subunits regulate cell adhesion through Rap1a and its effector RadilSpecificity in Ras and Rap signalingRole of EPAC in cAMP-Mediated Actions in Adrenocortical CellsInvestigation of cAMP microdomains as a path to novel cancer diagnosticsCell physiology of cAMP sensor Epac.Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiationDownregulation of Rap1GAP contributes to Ras transformationEpac2 induces synapse remodeling and depression and its disease-associated forms alter spinesSrc-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiationRap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activationCool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretionThe interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.Epac2-mediated dendritic spine remodeling: implications for disease.Direct spatial control of Epac1 by cyclic AMP.Prostaglandins in bone: bad cop, good cop?Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.The future of EPAC-targeted therapies: agonism versus antagonismEpac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoformsEpac activation sensitizes rat sensory neurons through activation of Ras.Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteinsEPAC proteins transduce diverse cellular actions of cAMP.A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.The role of Epac in the heart.Ras GTPases' interaction with effector domains: Breaking the families' barrier.PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation.The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.
P2860
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P2860
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
description
2006 nî lūn-bûn
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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2006 թվականի փետրվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@ast
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en-gb
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@nl
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The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@ast
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en-gb
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@nl
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The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@ast
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en-gb
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@nl
P2093
P2860
P3181
P356
P1476
The RAP1 guanine nucleotide ex ...... signals at the plasma membrane
@en
P2093
Ariel F Castro
John F Rebhun
Lawrence A Quilliam
Nivanka C Paranavitana
Sirisha Asuri
P2860
P304
P3181
P356
10.1074/JBC.M508165200
P407
P577
2006-02-03T00:00:00Z