Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
about
Mitochondria, calcium and cell death: a deadly triad in neurodegenerationConditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegenerationRole of ROS and RNS Sources in Physiological and Pathological ConditionsThe synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degenerationEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Protein transamidation by transglutaminase 2 in cells: a disputed Ca2+-dependent action of a multifunctional proteinDeranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegansMitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDsCardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's diseaseReduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis.Alzheimer's disease and neuronal network activityMutagenesis mapping of the presenilin 1 calcium leak conductance pore.Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice.An overview of APP processing enzymes and products.Progressive age-related impairment of the late long-term potentiation in Alzheimer's disease presenilin-1 mutant knock-in miceInositol trisphosphate receptor Ca2+ release channels in neurological diseases.Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.Role of presenilins in neuronal calcium homeostasisProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.Regulation of Ca2+ signaling with particular focus on mast cells.Early calcium dysregulation in Alzheimer's disease: setting the stage for synaptic dysfunction.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's diseaseExcitability and synaptic alterations in the cerebellum of APP/PS1 miceThe C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.A platelet protein biochip rapidly detects an Alzheimer's disease-specific phenotypePresenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.Bilayer measurement of endoplasmic reticulum Ca2+ channels.Endoplasmic reticulum Ca(2+) handling in excitable cells in health and diseaseConstitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channelsPhysiology and pathology of calcium signaling in the brain.Presenilins: a novel link between intracellular calcium signaling and lysosomal function?Mitochondrial Ca(2+) and neurodegenerationNeuronal calcium mishandling and the pathogenesis of Alzheimer's disease
P2860
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P2860
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@ast
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en-gb
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@nl
type
label
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@ast
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en-gb
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@nl
prefLabel
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@ast
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en-gb
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@nl
P2093
P2860
P921
P3181
P356
P1476
Familial Alzheimer disease-lin ...... leak function of presenilin 1
@en
P2093
Bart de Strooper
Huiping Tu
Ilya Bezprozvanny
Mostafa Bentahir
Omar Nelson
Tianhua Lei
P2860
P304
P3181
P356
10.1172/JCI30447
P407
P577
2007-05-01T00:00:00Z