Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. - sprookjes - yvandenbroek - TriplyDB

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

http://www.wikidata.org/entity/Q33554241

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Mitochondria-associated ER membranes and Alzheimer disease STIM and ORAI proteins in the nervous system Synaptic dysfunction and septin protein family members in neurodegenerative diseases Autism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling.Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour.Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes.Physiological Function and Characterization of TRPCs in Neurons Our "energy-Ca(2+) signaling deficits" hypothesis and its explanatory potential for key features of Alzheimer's disease.STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.Differential role of STIM1 and STIM2 during transient inward (T in) current generation and the maturation process in the Xenopus oocyte Stim and Orai proteins in neuronal Ca(2+) signaling and excitability STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease Differentially expressed genes linked to natural variation in long-term memory formation in Cotesia parasitic wasps Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model.Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease Preface.Calcium signaling, excitability, and synaptic plasticity defects in a mouse model of Alzheimer's disease Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear.AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons.Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons.Endoplasmic reticulum calcium stores in dendritic spines Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.Roles of Calcium Stores and Store-Operated Channels in Plasticity of Dendritic Spines.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.Calcium's role as nuanced modulator of cellular physiology in the brain.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?Emerging pathways driving early synaptic pathology in Alzheimer's disease.Role of STIM2 in cell function and physiopathology.IP3 receptor mutations and brain diseases in human and rodents.Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.

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Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.

http://www.wikidata.org/entity/Q33554241

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2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

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2014年の論文

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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J.NEURON.2014.02.019

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Reduced synaptic STIM2 express ...... nes in mutant presenilin mice.

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Elena Popugaeva

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Hua Zhang

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Ilya Bezprozvanny

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Jie Liu

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Suya Sun

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P2860

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

Postsynaptic signaling during plasticity of dendritic spines

Mechanisms of CaMKII action in long-term potentiation

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

Structure of a presenilin family intramembrane aspartate protease

Structure-stability-function relationships of dendritic spines

STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease

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Charles L White

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