Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
about
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteinsA Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulationA novel role of Sprouty 2 in regulating cellular apoptosisThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitiSprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesThe role of targeted protein degradation in early neural developmentAdditional Serine/Threonine Phosphorylation Reduces Binding Affinity but Preserves Interface Topography of Substrate Proteins to the c-Cbl TKB DomainA functional interaction between sprouty proteins and caveolin-1Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pitsRegulation of sprouty stability by Mnk1-dependent phosphorylation.Cbl controls EGFR fate by regulating early endosome fusion.The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loopSprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoidsThe developing story of Sprouty and cancer.Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2.Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation.Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cellsSPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferationTesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Sprouty is a cytoplasmic target of adenoviral E1A oncoproteins to regulate the receptor tyrosine kinase signalling pathwayIdentification of a new Sprouty protein responsible for the inhibition of the Bombyx mori nucleopolyhedrovirus reproductionRegulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteinsc-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.ERK MAP kinase in G cell cycle progression and cancer.Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasiahCG-induced Sprouty2 mediates amphiregulin-stimulated COX-2/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS.Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.Sprouty2 interacts with protein kinase C delta and disrupts phosphorylation of protein kinase D1.Intermolecular interactions of Sprouty proteins and their implications in development and disease.Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.Sprouty 2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release.Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes.
P2860
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P2860
Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@ast
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en-gb
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@nl
type
label
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@ast
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en-gb
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@nl
prefLabel
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@ast
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en-gb
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@nl
P2093
P2860
P3181
P356
P1476
Tyrosine phosphorylation of Sp ...... nd is crucial for its function
@en
P2093
Chee Wai Fong
Esther Sook Miin Wong
Graeme R Guy
Hwei Fen Leong
Jormay Lim
Permeen Yusoff
P2860
P304
P3181
P356
10.1074/JBC.M301317200
P407
P577
2003-08-29T00:00:00Z