The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins - sprookjes - yvandenbroek - TriplyDB

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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A novel role of Sprouty 2 in regulating cellular apoptosis Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function The role of the ubiquitination-proteasome pathway in breast cancer: ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability A functional interaction between sprouty proteins and caveolin-1 Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia Coordinating ERK/MAPK signalling through scaffolds and inhibitors Regulation of sprouty stability by Mnk1-dependent phosphorylation.Modeling cancer progression via pathway dependencies The VASP-Spred-Sprouty domain puzzle.How Genetics Has Helped Piece Together the MAPK Signaling Pathway.HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2.Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.The developing story of Sprouty and cancer.Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis.Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation E3 ubiquitin ligases as regulators of membrane protein trafficking and degradation.Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract.Current challenges in quantitative modeling of epidermal growth factor signaling.Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway.hCG-induced Sprouty2 mediates amphiregulin-stimulated COX-2/PGE2 up-regulation in human granulosa cells: a potential mechanism for the OHSS.Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells Intermolecular interactions of Sprouty proteins and their implications in development and disease.Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells.

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

http://www.wikidata.org/entity/Q24534190

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2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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type

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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prefLabel

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins

@en

P2093

Amy B Hall

http://www.w3.org/2001/XMLSchema#string

Bogdan A Yatsula

http://www.w3.org/2001/XMLSchema#string

James E Egan

http://www.w3.org/2001/XMLSchema#string

P2860

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

Cell signaling by receptor tyrosine kinases

Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain

Evidence for direct interaction between Sprouty and Cbl

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis

Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis

Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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6041-6046

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scholarly article

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3987143

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10.1073/PNAS.052090899

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9

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99

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11983899

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122898

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