Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 - sprookjes - yvandenbroek - TriplyDB

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

http://www.wikidata.org/entity/Q24306213

about

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers Targeting Protein-Protein Interactions in the HIF System Hypoxia and metabolic adaptation of cancer cells Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes.Global microRNA depletion suppresses tumor angiogenesis.Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)Increased hypoxia-inducible factor 1α expression in lung cells of horses with recurrent airway obstruction.Erythropoietin after a century of research: younger than ever.The rate-limiting step of O2 activation in the α-ketoglutarate oxygenase factor inhibiting hypoxia inducible factor.New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens.Oxygen sensing in cancer.Hypoxia-inducible factor-1 and oncogenic signalling.Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion Oxygen sensing: getting pumped by sterols.HIF-1α pathway: role, regulation and intervention for cancer therapy.Development of novel therapeutic strategies that target HIF-1.Redox regulation of the hypoxia-inducible factor.Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1.SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.Metabolic transformation in cancer.Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2.Targeting the hypoxia-inducible factor (HIF) pathway in cancer.Ischemia-induced copper loss and suppression of angiogenesis in the pathogenesis of myocardial infarction.Hypoxia-inducible factor (HIF) network: insights from mathematical models.Human activated macrophages and hypoxia: a comprehensive review of the literature.Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates.Hypoxia inducible factors in hepatocellular carcinoma Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.HIF-1 in cancer therapy: two decade long story of a transcription factor.The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia.Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function.

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P2860

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

http://www.wikidata.org/entity/Q24306213

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

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Biochemical Journal

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Hypoxia-inducible factor aspar ...... beta-carbon of asparagine-803

@en

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Jürgen F Seibel

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Kirsty S Hewitson

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Luke A McNeill

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Timothy D Claridge

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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571-5

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scholarly article

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4293730

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10.1042/BJ20021162

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P433

Pt 3

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P478

367

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Christopher J. Schofield

Louise E Horsfall

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2002-11-01T00:00:00Z

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11174366

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P698

12215170

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P921

oxidation-reduction process

peptidyl-asparagine 3-dioxygenase activity

Hypoxia inducible factor 1 subunit alpha inhibitor

P932

1222951

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