FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor - sprookjes - yvandenbroek - TriplyDB

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

http://www.wikidata.org/entity/Q24300161

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Cloning and expression analysis of two distinct HIF-alpha isoforms--gcHIF-1alpha and gcHIF-4alpha--from the hypoxia-tolerant grass carp, Ctenopharyngodon idellus PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia Expanding role of the jumonji C domain as an RNA hydroxylase JMJD6 is a histone arginine demethylase Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803 Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1 MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1 Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1 Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity Hypoxic regulation of erythropoiesis and iron metabolism The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases The VHL tumor suppressor: master regulator of HIF Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha Regulation of hypoxia-inducible factor-1alpha by NF-kappaB HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers Molecular responses to hypoxia in tumor cells aHIF but not HIF-1alpha transcript is a poor prognostic marker in human breast cancer Ascorbate depletion: a critical step in nickel carcinogenesis?Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers Hypoxia and its implications in rheumatoid arthritis

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

http://www.wikidata.org/entity/Q24300161

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002 թվականի հունիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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type

label

FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

@ast

FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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prefLabel

FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

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FIH-1 is an asparaginyl hydrox ...... ty of hypoxia-inducible factor

@en

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Dean A Whelan

http://www.w3.org/2001/XMLSchema#string

Jeffrey J Gorman

http://www.w3.org/2001/XMLSchema#string

Murray L Whitelaw

http://www.w3.org/2001/XMLSchema#string

Richard K Bruick

http://www.w3.org/2001/XMLSchema#string

P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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1466-71

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1811666

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10.1101/GAD.991402

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12

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16

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2002-06-15T00:00:00Z

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11295253

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12080085

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oxidation-reduction process

Hypoxia inducible factor 1 subunit alpha inhibitor

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186346

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