ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
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Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonanceA novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kineticsPositive and negative regulation of T-cell activation through kinases and phosphatasesSignalling pathways induced by protease-activated receptors and integrins in T cellsVav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathwaysSpecific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complexKos1, a nonreceptor tyrosine kinase that suppresses Ras signalingPhosphorylation site dynamics of early T-cell receptor signalingCD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Reconstitution of the B cell antigen receptor signaling components in COS cellsPhosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitroT cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins.Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment.The cytoskeleton-associated TCR zeta chain is constitutively phosphorylated in the absence of an active p56(lck) form.Organization of proximal signal initiation at the TCR:CD3 complex.ITAM-mediated signaling by the T-cell antigen receptorA cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells.Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection.Genetic analysis of integrin activation in T lymphocytes.Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulationQualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosisFunction of CD3 epsilon-mediated signals in T cell developmentRequirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell developmentInvolvement of the TCR Cbeta FG loop in thymic selection and T cell function.Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization.One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs.Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.Induction and stability of the anergic phenotype in T cellsThe middle ear immune defense changes with age.Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells.Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.
P2860
Q24319958-E2294A87-88CA-485A-A790-993D8806C514Q24320182-5165CF50-63D4-491A-9519-306BEFA9DDC1Q24324474-CE347C4B-37E1-4ED0-9159-3BC9F2B12ACBQ24535649-85520165-F003-4192-9E8A-0C59EF207030Q24682815-631EB427-9015-4A5B-ACDB-D4F8FDA24F5DQ28208330-688F4D8C-8F83-41FB-B852-BAB371640575Q28278183-69EA3577-B7F6-494C-927D-7F21FDAF70AEQ28506012-00693E50-46ED-49E9-A162-15221B65F501Q28542511-CAA18046-8E2B-4DCC-BDE4-95C472F14340Q28589169-2615F9F7-68F2-4058-A2C6-E9EB737750ECQ28615680-B50ABE67-02C8-4CCA-AC32-5CF1FC7D2E1DQ28910383-316B4360-D1AA-4534-9017-DECF7747BEDCQ30175390-7CB3BBE3-7876-4A3D-96CC-1E1DB4650A34Q30497743-0D3ABD97-E227-4CD6-A9BD-D241CF93B68FQ31946988-09F14833-9E8C-4A7E-9A45-BF053EA050E3Q33753888-C01BEEDC-7D4E-470E-AC03-08DEB4DAE35FQ33849367-763D7458-1271-4A13-8055-C286893C1AA8Q33852715-B4B0A5E6-2AB6-45F2-810A-3339C7F27C27Q34150054-B4E9EC3F-8BAC-4041-A9C8-100695EEC8DFQ34649554-009BA04B-B961-412A-BFB3-5456ED8564D1Q34666349-F71F8934-C6A6-48FA-A133-E3A521DAE065Q34862300-9F4FA129-1204-422C-977F-AEF96B8AE2F8Q36139263-CBE720B1-E22C-41DE-90BD-4DA917100993Q36266883-E6C64348-8B47-4711-A4FF-C4555D550AA4Q36288209-E52174AD-D564-4CDC-8D5B-A3616DF0BDF2Q36366675-FD1D92BE-CFAE-4B78-9DC1-7AD1E414623BQ36368886-8B1DDBDF-6DCB-4472-97B7-581B38DD041AQ36369507-4BDFD01B-5151-4C4D-9357-04C37B0E5783Q36369696-84AE9B1F-E654-40C1-BB46-9968BB50F235Q36380874-5103BC69-BB1B-4ED8-88FD-E0150AD3EAB8Q36399415-6FBBB382-07A2-4D6C-9952-1F0116C84BA0Q36400745-15CE9B5A-9A57-4AB9-8403-F402997119B5Q36850200-45987DBD-80F7-48D6-ABAE-228B8B2ABA26Q37270758-2EE6AD59-58EE-4DB2-B750-7EAAD00450AEQ37380253-18ED1516-5F75-4FA8-8D26-C5D6D23255DAQ37695679-B30B6D52-655A-4955-A1DC-FCF4F384C541Q38161200-2774D490-F01C-48FC-ADE8-0C27E7987D0BQ38301862-52455643-84DC-430F-ADB0-76EE87FDD3E0Q38342816-8FCA2A8E-8ABE-4CB1-AA2F-F4059020E969Q38667200-FDAF96E2-E753-4039-ADE5-D0C1346301F3
P2860
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
ZAP-70 binding specificity to ...... n motifs with varying affinity
@ast
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en-gb
ZAP-70 binding specificity to ...... n motifs with varying affinity
@nl
type
label
ZAP-70 binding specificity to ...... n motifs with varying affinity
@ast
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en-gb
ZAP-70 binding specificity to ...... n motifs with varying affinity
@nl
prefLabel
ZAP-70 binding specificity to ...... n motifs with varying affinity
@ast
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en-gb
ZAP-70 binding specificity to ...... n motifs with varying affinity
@nl
P2093
P2860
P356
P1476
ZAP-70 binding specificity to ...... n motifs with varying affinity
@en
P2093
L E Samelson
R Aebersold
W H Burgess
P2860
P304
P356
10.1084/JEM.181.1.375
P407
P577
1995-01-01T00:00:00Z