Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
about
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationTyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckSLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activityCAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cellsFYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cellsFunctional association between SLAP-130 and SLP-76 in Jurkat T cellsThe transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chainNFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signalingZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinityPhosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1Cp56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulationMolecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytesCloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 productionImmunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cellsFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsMechanism of activation for Zap-70 catalytic activityAnalysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonanceInteraction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signalingThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationInteraction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kineticsMapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cellsDynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector moleculesA novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptorDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionBinding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteinsT cell activationTyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingAssociation of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transductionRole of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signalingSyk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complexFc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseasesCa2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migrationInteraction of SLP adaptors with the SH2 domain of Tec family kinasesNovel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 productionItk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesTyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinasesSyk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cellsInteractions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells
P2860
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P2860
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
description
1994 nî lūn-bûn
@nan
1994 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@ast
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en-gb
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@nl
type
label
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@ast
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en-gb
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@nl
prefLabel
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@ast
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en-gb
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@nl
P2093
P3181
P356
P1433
P1476
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.7509083
P407
P577
1994-02-25T00:00:00Z