Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
about
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)Dab2 links CIN85 with clathrin-mediated receptor internalizationFCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosisRegulation of the Wnt signaling pathway by disabled-2 (Dab2)Quantitative proteomics identifies a Dab2/integrin module regulating cell migrationCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinMona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.Dual roles for the Dab2 adaptor protein in embryonic development and kidney transportThe adaptor protein Disabled-2: new insights into platelet biology and integrin signalingEndocytosis and Physiology: Insights from Disabled-2 Deficient MiceDirect binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkACell cycle-dependent phosphorylation of Disabled-2 by cdc2The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifDisabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosisDisabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2PKB/Akt partners with Dab2 in albumin endocytosisThe inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancerType II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cellsNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayA lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegansPutative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma.Disabled-2 inactivation is an early step in ovarian tumorigenicity.The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells.Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.Disabled-2 downregulation promotes epithelial-to-mesenchymal transitionHormonal induction and roles of Disabled-2 in lactation and involution.Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight.Disabled-2 Determines Commitment of a Pre-adipocyte Population in Juvenile Mice.Coupled myosin VI motors facilitate unidirectional movement on an F-actin network.Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma.
P2860
Q24291279-77132DE6-AB5A-4B55-8582-857C1A8DBEF9Q24292232-59E38380-EDA3-4EA8-B96D-E5FAC565D49CQ24296708-A2947BB1-168E-4AF6-A04B-0981D5571C65Q24299168-573C9990-CFD9-4F4B-ABF8-92232365A36AQ24304997-F6D98C09-5B8C-4619-8F66-34CF0B4DD744Q24305113-7321E9EA-CA57-414A-BD18-76024BDC5210Q24311541-8FAAC825-AA07-452A-96A7-DC73A3CC08E8Q24532029-1A07D36B-EDFB-434F-9713-7168EADE8EAAQ24533474-4317617D-DBF1-49FD-A1BA-2F782EF25B97Q24536278-9092944E-2109-4AEB-A554-774C8E76C769Q28074277-23D93705-1929-4E96-ADFC-4BB90C3029EDQ28076375-77FEE958-BC5D-4BE2-AB9C-DF2F1B86ECD9Q28140629-3B495E35-4F4B-406D-9E53-ED7ED4313B19Q28189608-2127D536-DA70-4040-A5A5-BA962D725FA1Q28213947-A5645406-E2BA-435E-AB0A-7C18E6D543D2Q28508344-3D083CCA-27AD-48BE-9C83-8FDADD5FD634Q28510727-552E6073-4F58-4316-9053-118AA715AFE4Q28511801-0D08B675-6605-443A-B263-27E4217F39C8Q28569686-FDCAA38D-664A-4A5A-A6DE-2B527565E495Q28574447-954C42CE-8C93-48DB-922C-1D6C2C15D42BQ28581678-9E120468-08F8-4FC6-8529-748845FE2A56Q28588905-79A2A4F7-D8D4-4B97-A682-9795B9D7E194Q28590918-C7A48232-880A-490A-82D2-52773FF20DFAQ28608965-D27371B3-FC93-4B43-AD65-E59DD3EDA6F7Q30165412-9C345B08-9142-4CAD-B106-7069E55A55D4Q33594982-AB570AB3-290E-4312-86C3-A99F11CF4A4FQ33863070-CE746A54-1E1C-4DDE-A358-B8FA67E2A198Q33878504-21531D8A-AEF0-4CB0-99BC-E33CA886F2DBQ33922202-3637EAC8-5EAA-4A88-A699-1227754068C3Q34013092-55550D7D-4F3A-4E76-8FC2-6F01B9DEA060Q34028615-76ABAEC5-0CFE-49BC-AF01-463031D9B398Q34363558-4646E0A0-553A-431C-BFE7-9AF95DD0CA44Q34434655-71CC9476-FCC3-48F1-AB69-CBBBBB07937BQ34568457-7979F9F5-6FF3-4B6B-9E75-2B78692B7F6BQ35028025-E222E7D1-C995-4B83-97C5-11233DF38C6FQ35201865-27809596-8053-4BF2-B49B-4DBE78352645Q36793324-52AFBFDD-6093-4406-AAD7-D1416B889401Q37363945-E05B065E-80AB-440D-8063-BCC0A41907A0Q37387839-D59A3858-A6B1-405C-A209-7BD51BCB120BQ37687592-9CD1863F-51EC-4621-AD72-273B2D208D38
P2860
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@ast
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en-gb
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@nl
type
label
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@ast
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en-gb
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@nl
prefLabel
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@ast
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en-gb
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@nl
P2093
P921
P3181
P356
P1433
P1476
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
@en
P2093
P2888
P304
P3181
P356
10.1038/SJ.ONC.1201678
P407
P577
1998-03-26T00:00:00Z
P5875
P6179
1036905536