Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. - sprookjes - yvandenbroek - TriplyDB

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

http://www.wikidata.org/entity/Q34028615

about

Expression of GATA3 in MDA-MB-231 triple-negative breast cancer cells induces a growth inhibitory response to TGFß Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice Switching Roles of TGF-β in Cancer Development: Implications for Therapeutic Target and Biomarker Studies BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation Gene expression pathways of high grade localized prostate cancer.Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Dynamic regulation of Tgf-B signaling by Tif1γ: a computational approach.Hormonal induction and roles of Disabled-2 in lactation and involution.Identification of ovarian cancer associated genes using an integrated approach in a Boolean framework.miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.The translational significance of epithelial-mesenchymal transition in head and neck cancer.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Epithelial-mesenchymal transition in oral squamous cell carcinoma The cancer stem cell subtype determines immune infiltration of glioblastoma.The regulation of cell-cell adhesion during epithelial-mesenchymal transition, motility and tumor progression.Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems.The complexities of TGF-β action during mammary and squamous cell carcinogenesis.Targeting the TGFβ signalling pathway in disease.MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.PPARδ promotes oncogenic redirection of TGF-β1 signaling through the activation of the ABCA1-Cav1 pathway.The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma.Role of Smads in TGFβ signaling.Analysis of microRNA-target interactions across diverse cancer types.Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.TGF-β signaling in liver and gastrointestinal cancers Disabled-2: A modular scaffold protein with multifaceted functions in signaling.Intrinsic TGF-β2-triggered SDF-1-CXCR4 signaling axis is crucial for drug resistance and a slow-cycling state in bone marrow-disseminated tumor cells.Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β Targeting TGF-β Signaling for Therapeutic Gain.A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo.Transforming growth factor-β enhances invasion and metastasis in Ras-transfected human malignant epidermal keratinocytes.Casein kinase 2 regulates the mRNA-destabilizing activity of tristetraprolin.Disabled-2; an autophagic and apoptotic switch.Micro ribonucleic acid-93 promotes proliferation and migration of esophageal squamous cell carcinoma by targeting disabled 2 Endocytosis and cancer.

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P2860

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

http://www.wikidata.org/entity/Q34028615

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@ast

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@en

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@nl

type

label

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@ast

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@en

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@nl

prefLabel

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@ast

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@en

Epigenetic downregulation of h ...... uppressor to a tumor promoter.

@nl

P1433

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Journal of Clinical Investigation

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Epigenetic downregulation of h ...... suppressor to a tumor promoter

@en

P2093

Adèle Hannigan

http://www.w3.org/2001/XMLSchema#string

Blanca Herrera

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Clare Orange

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Darren I O'Brien

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David C K Chu

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Francesca M Buffa

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Gabriela Kalna

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Jelena Mann

http://www.w3.org/2001/XMLSchema#string

Johanna K Thurlow

http://www.w3.org/2001/XMLSchema#string

Jonathan A Cooper

http://www.w3.org/2001/XMLSchema#string

P2860

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

The Hallmarks of Cancer

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

Quantitative proteomics identifies a Dab2/integrin module regulating cell migration

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

P304

2842-2857

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scholarly article

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10.1172/JCI36125

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8

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120

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Adrian L Harris

Catharine M. West

Martino Monteverde

Margaret C Frame

Cristiana Lo Nigro

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2010-07-01T00:00:00Z

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20592473

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P932

2912175

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