Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
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Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivoBinding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway.The Nef protein of HIV-1 associates with rafts and primes T cells for activationHIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchAging and immune function: molecular mechanisms to interventionsHIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenonHIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Simian immunodeficiency virus and human immunodeficiency virus type 1 nef proteins show distinct patterns and mechanisms of Src kinase activation.Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspasesThe domain landscape of virus-host interactomesSequence- and interactome-based prediction of viral protein hotspots targeting host proteins: a case study for HIV Nef.HIV protein sequence hotspots for crosstalk with host hub proteins.HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.Human immunodeficiency virus type 1 Vif protein binds to the Pr55Gag precursor.Proteomic characterization of HIV-modulated membrane receptors, kinases and signaling proteins involved in novel angiogenic pathways.Inhibition of Kaposi's sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258.Cellular kinases incorporated into HIV-1 particles: passive or active passengers?The T-cell receptor zeta chain contains two homologous domains with which simian immunodeficiency virus Nef interacts and mediates down-modulation.Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.HIV-1 Nef and T-cell activation: a history of contradictions.Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway.Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ diseaseHIV-1 infection is facilitated in T cells by decreasing p56lck protein tyrosine kinase activity.SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
P2860
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P2860
Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
description
1996 nî lūn-bûn
@nan
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@ast
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en-gb
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@nl
type
label
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@ast
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en-gb
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@nl
prefLabel
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@ast
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en-gb
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@nl
P2093
P2860
P921
P1433
P1476
Human immunodeficiency virus t ...... se, inhibiting kinase activity
@en
P2093
P2860
P304
P407
P577
1996-10-01T00:00:00Z