LCK proto-oncogene, Src family tyrosine kinase

LCK proto-oncogene, Src family tyrosine kinase

Item
http://www.wikidata.org/entity/Q9020944
Q21113792
sameAs
LCK
P688
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationcDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changesMolecular basis for regulation of Src by the docking protein p130CasThe influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epitheliumThe CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complexThe influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationT cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceEvidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoproteinProfound block in thymocyte development in mice lacking p56lckRegulation of Fyn through translocation of activated Lck into lipid raftsCalpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cellsInteraction of p56lck with CD4 in the yeast two-hybrid systemThe SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytesDistinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesPhosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lckSrc family kinases in tumor progression and metastasisp70 phosphorylation and binding to p56lck is an early event in interleukin-2-induced onset of cell cycle progression in T-lymphocytesThe tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expressionCrystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifsHuman immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activityThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationPhosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal regionSteel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cellsGab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-KitTyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factorsKit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferationThe phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating LckPhosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitroWNK1 kinase balances T cell adhesion versus migration in vivoIn vitro membrane reconstitution of the T-cell receptor proximal signaling network.
P921

LCK proto-oncogene, Src family tyrosine kinase

Item
http://www.wikidata.org/entity/Q9020944
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in LCK proto-oncogene, Src family tyrosine kinase
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
LCK proto-oncogene, Src family tyrosine kinase
@en
Lck
@es
Lck
@ru
type
label
LCK proto-oncogene, Src family tyrosine kinase
@en
Lck
@es
Lck
@ru
altLabel
LCK
@en
LSK
@en
Protein YT16
@en
Proto-oncogene Lck
@en
T-lymphocyte specific protein tyrosine kinase p56lck
@en
leukocyte C-terminal Src kinase
@en
lymphocyte cell-specific protein-tyrosine kinase
@en
p56(LSTRA) protein-tyrosine kinase
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p56-LCK
@en
proto-oncogene tyrosine-protein kinase LCK
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prefLabel
LCK proto-oncogene, Src family tyrosine kinase
@en
Lck
@es
Lck
@ru
P129
P31
P352
P361
P527
P637
P638
P680
P681
P682
P692
P702
P703
P705
P352
P637
P638
P129
P31
P352
P361
P527
P637
P638
P680
P681
P682
P692
P702
P703
P705