TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
about
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame sizeCurrent Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic ApproachesGamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexAn alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitorProteinase-activated receptors, nucleotide P2Y receptors, and μ-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi traffickingThe amyloid precursor protein: beyond amyloidCellular mechanisms of γ-secretase substrate selection, processing and toxicityNew pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugsProtease regulation: the Yin and Yang of neural development and diseaseProton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavageStructural biology of presenilin 1 complexesAPP processing in Alzheimer's diseaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsThe in vivo brain interactome of the amyloid precursor proteinAn Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase ActivityAffinity pulldown of γ-secretase and associated proteins from human and rat brainp23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.Disparate effects of p24alpha and p24delta on secretory protein transport and processing.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domainsCellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.Characterization of an atypical gamma-secretase complex from hematopoietic originA novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.Notch inhibitors for cancer treatment.Expression of tmp21 in normal adult human tissues.The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate.Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted AbetaThe γ-secretase complex: from structure to function.Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's diseaseTranscriptional Regulation of TMP21 by NFAT.Loss of presenilin 2 is associated with increased iPLA2 activity and lung tumor development.
P2860
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P2860
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@ast
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en-gb
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@nl
type
label
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@ast
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en-gb
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@nl
prefLabel
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@ast
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en-gb
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@nl
P2093
P50
P356
P1433
P1476
TMP21 is a presenilin complex ...... not epsilon-secretase activity
@en
P2093
Anurag Tandon
Christopher Bohm
Fusheng Chen
Hiroshi Hasegawa
Kirk Hansen
Michael Glista
Paul Fraser
Raphaëlle Pardossi-Piquard
Taiichi Katayama
Xueying Ruan
P2888
P304
P356
10.1038/NATURE04667
P407
P50
P577
2006-04-27T00:00:00Z
P6179
1032240937