Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain. - sprookjes - yvandenbroek - TriplyDB

Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.

Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.

http://www.wikidata.org/entity/Q34252876

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Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage Complex regulation of γ-secretase: from obligatory to modulatory subunits Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action Development and mechanism of γ-secretase modulators for Alzheimer's disease.Oestrogens as modulators of neuronal signalosomes and brain lipid homeostasis related to protection against neurodegeneration.The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders.Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system.Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease.Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases.Protein-protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms.Association of AMD-like retinopathy development with an Alzheimer's disease metabolic pathway in OXYS rats.Human brain proteins showing neuron-specific interactions with γ-secretase.Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation.Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis

P2860

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P2860

Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.

http://www.wikidata.org/entity/Q34252876

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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type

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Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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prefLabel

Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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Identification of novel γ-secr ...... esistant membranes from brain.

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JBC.M111.246074

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Journal of Biological Chemistry

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Identification of novel γ-secr ...... esistant membranes from brain.

@en

P2093

Ji-Yeun Hur

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Lars O Tjernberg

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Masakazu Hashimoto

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Mitsuhiro Inoue

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Natsuko Goto Yamamoto

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Susanne Frykman

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Takahiro Kihara

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Waltteri Hosia

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Yasuhiro Teranishi

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P2860

Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Caspr regulates the processing of contactin and inhibits its binding to neurofascin

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

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10.1074/JBC.M111.246074

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2012-02-07T00:00:00Z

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