Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
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GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.Themis2 is not required for B cell development, activation, and antibody responses.Fine-tuning T cell receptor signaling to control T cell developmentTHEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.Differential function of Themis CABIT domains during T cell developmentIn vivo functional mapping of the conserved protein domains within murine Themis1THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs.Themis sets the signal threshold for positive and negative selection in T-cell developmentTHEMIS: Two Models, Different Thresholds.Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.Thymic progenitors of TCRαβ+ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development.Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.Themis2 lowers the threshold for B cell activation during positive selection.
P2860
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P248
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P2860
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Interchangeability of Themis1 ...... h conserved molecular function
@ast
Interchangeability of Themis1 ...... h conserved molecular function
@en
Interchangeability of Themis1 ...... h conserved molecular function
@en-gb
Interchangeability of Themis1 ...... h conserved molecular function
@nl
type
label
Interchangeability of Themis1 ...... h conserved molecular function
@ast
Interchangeability of Themis1 ...... h conserved molecular function
@en
Interchangeability of Themis1 ...... h conserved molecular function
@en-gb
Interchangeability of Themis1 ...... h conserved molecular function
@nl
prefLabel
Interchangeability of Themis1 ...... h conserved molecular function
@ast
Interchangeability of Themis1 ...... h conserved molecular function
@en
Interchangeability of Themis1 ...... h conserved molecular function
@en-gb
Interchangeability of Themis1 ...... h conserved molecular function
@nl
P2093
P2860
P921
P356
P1476
Interchangeability of Themis1 ...... h conserved molecular function
@en
P2093
Dalal El-Khoury
Ekaterina Zvezdova
Ki-Duk Song
Lawrence E Samelson
Paul E Love
Renaud Lesourne
Shoji Uehara
Valarie A Barr
P2860
P304
P356
10.4049/JIMMUNOL.1200123
P407
P577
2012-08-01T00:00:00Z