A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin - sprookjes - yvandenbroek - TriplyDB

A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin

A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin

http://www.wikidata.org/entity/Q24542617

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A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules Dishevelled-2 docks and activates Src in a Wnt-dependent manner The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling.Direct spatial control of Epac1 by cyclic AMP.Regulation of ciliary polarity by the APC/C.The structural and functional determinants of the Axin and Dishevelled DIX domains c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability.Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.Microarray analysis of gene expression profiles of Schistosoma japonicum derived from less-susceptible host water buffalo and susceptible host goat.The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca²⁺ signaling A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled Internalization is required for proper Wingless signaling in Drosophila melanogaster.Powerful Drosophila screens that paved the wingless pathway.Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin.Origin and evolution of dishevelled.Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra Neuronal activity and Wnt signaling act through Gsk3-beta to regulate axonal integrity in mature Drosophila olfactory sensory neurons.Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5 Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.Functional dissection of phosphorylation of Disheveled in Drosophila.Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.Analysis of dishevelled localization and function in the early sea urchin embryo.N-terminal part of Dishevelled DEP domain is required for Wnt/β-catenin signaling in mammalian cells Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo.

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A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin

http://www.wikidata.org/entity/Q24542617

description

2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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A mutational analysis of dishe ...... el suppressing alleles of axin

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Andrea Penton

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Andreas Wodarz

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Roel Nusse

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P2860

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

LDL-receptor-related proteins in Wnt signal transduction

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Molecular structure of frizzled, a Drosophila tissue polarity gene.

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

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