DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
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Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcriptionGSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with AxinInhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding proteinSynergistic activation of the Wnt signaling pathway by Dvl and casein kinase IepsilonDisulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modulesbeta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteinsPR72, a novel regulator of Wnt signaling required for Naked cuticle functionSubcellular distribution of Wnt pathway proteins in normal and neoplastic colonBinding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cellsRegulation of the Wnt signaling pathway by disabled-2 (Dab2)I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathwayInhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor proteinAxin localizes to the centrosome and is involved in microtubule nucleationMolecular basis of Wnt activation via the DIX domain protein Ccd1Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axinAxin facilitates Smad3 activation in the transforming growth factor beta signaling pathwayDishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-cateninWnt signal transduction pathwaysSUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stabilityDifferential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3The links between axin and carcinogenesisNuclear localization is required for Dishevelled function in Wnt/beta-catenin signalingRegulation of CTNNB1 signaling in gastric cancer and stem cellsToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesFrizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signalingAxin directly interacts with plakoglobin and regulates its stabilityDimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinaseCasein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathwaysCasein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-cateninAxin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilonA-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3betaAxin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwayThe DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanismsThe β-catenin destruction complexProtein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in XenopusDickkopfs and Wnt/β-catenin signalling in liver cancerSulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARαBoth the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis
P2860
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P248
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P2860
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@ast
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en-gb
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@nl
type
label
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@ast
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en-gb
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@nl
prefLabel
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@ast
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en-gb
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@nl
P2093
P2860
P3181
P356
P1476
DIX domains of Dvl and axin ar ...... egulate beta-catenin stability
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.19.6.4414
P407
P577
1999-06-01T00:00:00Z