Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
about
An Introduction to the Genetics of Normal and Defective HearingMyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesFunctional characterization of the human myosin-7a motor domainThe unconventional myosin-VIIa associates with lysosomesHuman myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epitheliaVezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complexFunctional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.Usher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapyMyosin VIIA mutation screening in 189 Usher syndrome type 1 patientsMutation profile of all 49 exons of the human myosin VIIA gene, and haplotype analysis, in Usher 1B families from diverse originsA role for myosin VI in postsynaptic structure and glutamate receptor endocytosisNonsyndromic hearing impairment: unparalleled heterogeneityBMP4 signaling is involved in the generation of inner ear sensory epithelia.Myosins in cell junctionsThe many different cellular functions of MYO7A in the retinaStructures of usher syndrome 1 proteins and their complexesA comprehensive review of retinal gene therapyUnconventional myosin VIIA is a novel A-kinase-anchoring proteinMyosin superfamily evolutionary historyPhotoreceptor renewal: a role for peripherin/rdsHarmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and functionVertebrate unconventional myosinsLive imaging the phagocytic activity of inner ear supporting cells in response to hair cell deathAbnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B proteinNovel compound heterozygous mutations in MYO7A Associated with Usher syndrome 1 in a Chinese familyIn vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea.Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 miceRole of myosin VIIa and Rab27a in the motility and localization of RPE melanosomesThe Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factorFCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.A FERM domain autoregulates Drosophila myosin 7a activity.Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.Severe hearing loss and outer hair cell death in homozygous Foxo3 knockout mice after moderate noise exposure.Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice.Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities.myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis.
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P2860
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@ast
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@en
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@nl
type
label
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@ast
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@en
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@nl
prefLabel
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@ast
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@en
Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@nl
P2093
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Expression in cochlea and reti ...... tive in Usher syndrome type 1B
@en
P2093
J Santos-Sacchi
M B Heintzelman
M S Mooseker
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P304
P3181
P356
10.1073/PNAS.92.21.9815
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P577
1995-10-01T00:00:00Z