Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein
about
Functional characterization of the human myosin-7a motor domainThe unconventional myosin-VIIa associates with lysosomesUsher syndrome: animal models, retinal function of Usher proteins, and prospects for gene therapyUsherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cellsRelationship between Oxidative Stress, Circadian Rhythms, and AMDThe many different cellular functions of MYO7A in the retinaAutophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationA comprehensive review of retinal gene therapyTyro3 Modulates Mertk-Associated Retinal DegenerationMicrotubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathyMouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptorsRole of myosin VIIa and Rab27a in the motility and localization of RPE melanosomesThe Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cellsDrosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities.myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.Deafness and retinal degeneration in a novel USH1C knock-in mouse modelThe ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium.A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.Function of MYO7A in the human RPE and the validity of shaker1 mice as a model for Usher syndrome 1BRetinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence.Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouseMyosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayersMyosin7a deficiency results in reduced retinal activity which is improved by gene therapy.Novel and recurrent MYO7A mutations in Usher syndrome type 1 and type 2.Phagocytosis of retinal rod and cone photoreceptors.Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells.Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1.The retinal pigment epithelium in health and diseaseUnderstanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture.Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium.Reinforcement of a minor alternative splicing event in MYO7A due to a missense mutation results in a mild form of retinopathy and deafness.Rab GTPases and myosin motors in organelle motility.Analysis of photoreceptor rod outer segment phagocytosis by RPE cells in situ.
P2860
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P2860
Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2003
@ast
im Mai 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/05/27)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/05/27)
@nl
наукова стаття, опублікована в травні 2003
@uk
name
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@ast
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@en
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@nl
type
label
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@ast
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@en
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@nl
prefLabel
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@ast
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@en
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@nl
P2093
P2860
P3181
P356
P1476
Abnormal phagocytosis by retin ...... the Usher syndrome 1B protein
@en
P2093
Daniel Gibbs
David S. Williams
Junko Kitamoto
P2860
P304
P3181
P356
10.1073/PNAS.1130432100
P407
P577
2003-05-27T00:00:00Z