Suppression of tumorigenesis by the p53 target PUMA - sprookjes - yvandenbroek - TriplyDB

Suppression of tumorigenesis by the p53 target PUMA

Suppression of tumorigenesis by the p53 target PUMA

http://www.wikidata.org/entity/Q24563144

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Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells The Bcl-2 apoptotic switch in cancer development and therapy PUMA, a potent killer with or without p53 Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction Tumor suppressor p53 and its gain-of-function mutants in cancer Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein A microRNA polycistron as a potential human oncogene SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events Chd5 requires PHD-mediated histone 3 binding for tumor suppression Topoisomerase levels determine chemotherapy responsein vitroandin vivo The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Prognostic impact of bim, puma, and noxa expression in human colon carcinomas.BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphoma MYC levels govern hematopoietic tumor type and latency in transgenic mice ROS/p38/p53/Puma signaling pathway is involved in emodin-induced apoptosis of human colorectal cancer cells.BH3-only proteins in apoptosis at a glance Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression Life in the balance: how BH3-only proteins induce apoptosis.Oncogenes in cell survival and cell death.BH3-only proteins: integrated control point of apoptosis.BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.

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P2860

Suppression of tumorigenesis by the p53 target PUMA

http://www.wikidata.org/entity/Q24563144

description

2004 nî lūn-bûn

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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2004 թվականի հունիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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name

Suppression of tumorigenesis by the p53 target PUMA

@ast

Suppression of tumorigenesis by the p53 target PUMA

@en

Suppression of tumorigenesis by the p53 target PUMA

@nl

type

label

Suppression of tumorigenesis by the p53 target PUMA

@ast

Suppression of tumorigenesis by the p53 target PUMA

@en

Suppression of tumorigenesis by the p53 target PUMA

@nl

prefLabel

Suppression of tumorigenesis by the p53 target PUMA

@ast

Suppression of tumorigenesis by the p53 target PUMA

@en

Suppression of tumorigenesis by the p53 target PUMA

@nl

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PNAS.0403286101

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Suppression of tumorigenesis by the p53 target PUMA

@en

P2093

Jack T Zilfou

http://www.w3.org/2001/XMLSchema#string

Michael T Hemann

http://www.w3.org/2001/XMLSchema#string

Scott W Lowe

http://www.w3.org/2001/XMLSchema#string

Zhen Zhao

http://www.w3.org/2001/XMLSchema#string

P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

PUMA induces the rapid apoptosis of colorectal cancer cells

PUMA, a novel proapoptotic gene, is induced by p53

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

Surfing the p53 network

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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9333-9338

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scholarly article

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10.1073/PNAS.0403286101

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25

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101

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Darren J. Burgess

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8515578

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438977

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