about
Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cellsThe Bcl-2 apoptotic switch in cancer development and therapyPUMA, a potent killer with or without p53Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis inductionTumor suppressor p53 and its gain-of-function mutants in cancerCrystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only proteinA microRNA polycistron as a potential human oncogeneSMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial eventsChd5 requires PHD-mediated histone 3 binding for tumor suppressionTopoisomerase levels determine chemotherapy responsein vitroandin vivoThe liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice.A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma modelLoss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASFDeletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiationp53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Prognostic impact of bim, puma, and noxa expression in human colon carcinomas.BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages.Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy functionEndogenous Bcl-xL is essential for Myc-driven lymphomagenesis in miceDistinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis.Endogenous bcl-2 is not required for the development of Emu-myc-induced B-cell lymphomaMYC levels govern hematopoietic tumor type and latency in transgenic miceROS/p38/p53/Puma signaling pathway is involved in emodin-induced apoptosis of human colorectal cancer cells.BH3-only proteins in apoptosis at a glanceBim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppressionLife in the balance: how BH3-only proteins induce apoptosis.Oncogenes in cell survival and cell death.BH3-only proteins: integrated control point of apoptosis.BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Suppression of tumorigenesis by the p53 target PUMA
@ast
Suppression of tumorigenesis by the p53 target PUMA
@en
Suppression of tumorigenesis by the p53 target PUMA
@nl
type
label
Suppression of tumorigenesis by the p53 target PUMA
@ast
Suppression of tumorigenesis by the p53 target PUMA
@en
Suppression of tumorigenesis by the p53 target PUMA
@nl
prefLabel
Suppression of tumorigenesis by the p53 target PUMA
@ast
Suppression of tumorigenesis by the p53 target PUMA
@en
Suppression of tumorigenesis by the p53 target PUMA
@nl
P2093
P2860
P356
P1476
Suppression of tumorigenesis by the p53 target PUMA
@en
P2093
Jack T Zilfou
Michael T Hemann
Scott W Lowe
P2860
P304
P356
10.1073/PNAS.0403286101
P407
P577
2004-06-10T00:00:00Z