Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
about
The function of APC/CCdh1 in cell cycle and beyondSusceptibility of the aging lung to environmental injuryOverexpression of MYC causes p53-dependent G2 arrest of normal fibroblastsPhysical and functional interaction between PML and TBX2 in the establishment of cellular senescenceThe emerging importance of group II PAKsConstitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescenceMOZ increases p53 acetylation and premature senescence through its complex formation with PMLDNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulationEvidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cellsSuppression of tumorigenesis by the p53 target PUMATwist is a potential oncogene that inhibits apoptosisSenescence of activated stellate cells limits liver fibrosisSkp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescenceCellular senescence and tumor suppressor gene p16p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanismsEpstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosisDevelopmental context determines latency of MYC-induced tumorigenesisCatabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritisSenescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based TherapyMolecular mechanisms of biological aging in intervertebral discsDisruptive chemicals, senescence and immortalityMechanisms of disseminated cancer cell dormancy: an awakening fieldStem cells, senescence, neosis and self-renewal in cancer.A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformationJDP2 (Jun Dimerization Protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescenceEGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-IPEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescencep53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascadesA senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationInhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expressionAcidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian developmentAblation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressorFunctional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survivalSuppression of replicative senescence by rapamycin in rodent embryonic cellsRabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cellsThe p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
P2860
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P2860
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@ast
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en-gb
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@nl
type
label
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@ast
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en-gb
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@nl
prefLabel
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@ast
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en-gb
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Premature senescence involving ...... e MEK/MAPK mitogenic signaling
@en
P2093
P2860
P304
P3181
P356
10.1101/GAD.12.19.3008
P407
P577
1998-10-01T00:00:00Z