Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists - sprookjes - yvandenbroek - TriplyDB

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

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Landmarks in insulin research How insulin engages its primary binding site on the insulin receptor Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation Protective hinge in insulin opens to enable its receptor engagement Remembering donald f. Steiner Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation.Insulin receptor activation with transmembrane domain ligands.Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms.Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.Activation of transmembrane cell-surface receptors via a common mechanism? The "rotation model".Agonism and antagonism at the insulin receptor.Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling Flexibility in the insulin receptor ectodomain enables docking of insulin in crystallographic conformation observed in a hormone-bound microreceptor.Adventures with insulin in the islets of Langerhans Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity How IGF-1 activates its receptor.Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II.Molecular Dynamics Simulations of Insulin: Elucidating the Conformational Changes that Enable Its Binding α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2.A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.Theoretical and computational studies of peptides and receptors of the insulin family.Insulin mimetic peptide S371 folds into a helical structure.Crystallization of a challenging antigen-antibody complex: TLR3 ECD with three noncompeting Fabs.Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.Are all regions of folded proteins that undergo ligand-dependent order-disorder transitions targets for allosteric peptide mimetics?A docking study of insulin with LI-CR-L2 ecto domain of insulin receptor: an easy way for preliminary screening of novel anti-diabetic peptides A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.Insulin Receptor Isoforms in Physiology and Disease: An Updated View.Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.How ligand binds to the type 1 insulin-like growth factor receptor.

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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

http://www.wikidata.org/entity/Q24613113

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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Structural resolution of a tan ...... for design of peptide agonists

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PNAS.1001813107

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Proceedings of the National Academy of Sciences of the United States of America

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Structural resolution of a tan ...... for design of peptide agonists

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Colin W Ward

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Donald F Steiner

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Geoffrey Kong

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Jonathan Whittaker

http://www.w3.org/2001/XMLSchema#string

Kun Huang

http://www.w3.org/2001/XMLSchema#string

Michael A Weiss

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Panayotis G Katsoyannis

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Satoe Nakagawa

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Shi-Quan Hu

http://www.w3.org/2001/XMLSchema#string

Shu Jin Chan

http://www.w3.org/2001/XMLSchema#string

P2860

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

Design of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONS

Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

Shape complementarity at protein/protein interfaces

GROMACS: fast, flexible, and free

PHENIX: building new software for automated crystallographic structure determination

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

Insulin and its receptor: structure, function and evolution.

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10.1073/PNAS.1001813107

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107

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Michael C Lawrence

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2010-04-13T00:00:00Z

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